Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study

Small RNAs (sRNAs) are epigenetic regulators of essential biological processes associated with the development and progression of leukemias, including adult T-cell leukemia/lymphoma (ATLL) caused by human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic human retrovirus originally discovered...

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Autores principales: Pessôa, Rodrigo, de Souza, Daniela Raguer Valadão, Nukui, Youko, Pereira, Juliana, Fernandes, Lorena Abreu, Marcusso, Rosa Nascimento, de Oliveira, Augusto César Penalva, Casseb, Jorge, da Silva Duarte, Alberto José, Sanabani, Sabri Saeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342019/
https://www.ncbi.nlm.nih.gov/pubmed/37445821
http://dx.doi.org/10.3390/ijms241310643
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author Pessôa, Rodrigo
de Souza, Daniela Raguer Valadão
Nukui, Youko
Pereira, Juliana
Fernandes, Lorena Abreu
Marcusso, Rosa Nascimento
de Oliveira, Augusto César Penalva
Casseb, Jorge
da Silva Duarte, Alberto José
Sanabani, Sabri Saeed
author_facet Pessôa, Rodrigo
de Souza, Daniela Raguer Valadão
Nukui, Youko
Pereira, Juliana
Fernandes, Lorena Abreu
Marcusso, Rosa Nascimento
de Oliveira, Augusto César Penalva
Casseb, Jorge
da Silva Duarte, Alberto José
Sanabani, Sabri Saeed
author_sort Pessôa, Rodrigo
collection PubMed
description Small RNAs (sRNAs) are epigenetic regulators of essential biological processes associated with the development and progression of leukemias, including adult T-cell leukemia/lymphoma (ATLL) caused by human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic human retrovirus originally discovered in a patient with adult T-cell leukemia/lymphoma. Here, we describe the sRNA profile of a 30-year-old woman with ATLL at the time of diagnosis and after maintenance therapy with the aim of correlating expression levels with response to therapy.
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spelling pubmed-103420192023-07-14 Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study Pessôa, Rodrigo de Souza, Daniela Raguer Valadão Nukui, Youko Pereira, Juliana Fernandes, Lorena Abreu Marcusso, Rosa Nascimento de Oliveira, Augusto César Penalva Casseb, Jorge da Silva Duarte, Alberto José Sanabani, Sabri Saeed Int J Mol Sci Case Report Small RNAs (sRNAs) are epigenetic regulators of essential biological processes associated with the development and progression of leukemias, including adult T-cell leukemia/lymphoma (ATLL) caused by human T-cell lymphotropic virus type 1 (HTLV-1), an oncogenic human retrovirus originally discovered in a patient with adult T-cell leukemia/lymphoma. Here, we describe the sRNA profile of a 30-year-old woman with ATLL at the time of diagnosis and after maintenance therapy with the aim of correlating expression levels with response to therapy. MDPI 2023-06-26 /pmc/articles/PMC10342019/ /pubmed/37445821 http://dx.doi.org/10.3390/ijms241310643 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Pessôa, Rodrigo
de Souza, Daniela Raguer Valadão
Nukui, Youko
Pereira, Juliana
Fernandes, Lorena Abreu
Marcusso, Rosa Nascimento
de Oliveira, Augusto César Penalva
Casseb, Jorge
da Silva Duarte, Alberto José
Sanabani, Sabri Saeed
Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study
title Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study
title_full Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study
title_fullStr Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study
title_full_unstemmed Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study
title_short Small RNA Profiling in an HTLV-1-Infected Patient with Acute Adult T-Cell Leukemia-Lymphoma at Diagnosis and after Maintenance Therapy: A Case Study
title_sort small rna profiling in an htlv-1-infected patient with acute adult t-cell leukemia-lymphoma at diagnosis and after maintenance therapy: a case study
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342019/
https://www.ncbi.nlm.nih.gov/pubmed/37445821
http://dx.doi.org/10.3390/ijms241310643
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