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Molecular Dynamics Simulations Combined with Markov Model to Explore the Effect of Allosteric Inhibitor Binding on Bromodomain-Containing Protein 4

Bromodomain-Containing Protein 4 (BRD4) can play an important role in gene transcriptional regulation of tumor development and survival by participating in histone modification epigenetic mechanism. Although it has been reported that novel allosteric inhibitors such as ZL0590 have a high affinity wi...

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Detalles Bibliográficos
Autores principales:	Yang, Xiaotang, Gao, Yilin, Cao, Fuyan, Wang, Song
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342045/ https://www.ncbi.nlm.nih.gov/pubmed/37446009 http://dx.doi.org/10.3390/ijms241310831

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