Successful Use of Methylene Blue in Catecholamine-Resistant Septic Shock: A Case Report and Short Literature Review

Despite efforts to improve treatment outcomes, mortality in septic shock remains high. In some patients, despite the use of several adrenergic drugs, features of refractory vasoplegic shock with progressive multiorgan failure are observed. We present a case report of the successful reversal of vasop...

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Autores principales: Pluta, Michał P., Putowski, Zbigniew, Czempik, Piotr F., Krzych, Łukasz J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342053/
https://www.ncbi.nlm.nih.gov/pubmed/37445952
http://dx.doi.org/10.3390/ijms241310772
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author Pluta, Michał P.
Putowski, Zbigniew
Czempik, Piotr F.
Krzych, Łukasz J.
author_facet Pluta, Michał P.
Putowski, Zbigniew
Czempik, Piotr F.
Krzych, Łukasz J.
author_sort Pluta, Michał P.
collection PubMed
description Despite efforts to improve treatment outcomes, mortality in septic shock remains high. In some patients, despite the use of several adrenergic drugs, features of refractory vasoplegic shock with progressive multiorgan failure are observed. We present a case report of the successful reversal of vasoplegic shock following the use of methylene blue, a selective inhibitor of the inducible form of nitric oxide synthase, which prevents vasodilation in response to inflammatory cytokines. We also briefly review the literature.
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spelling pubmed-103420532023-07-14 Successful Use of Methylene Blue in Catecholamine-Resistant Septic Shock: A Case Report and Short Literature Review Pluta, Michał P. Putowski, Zbigniew Czempik, Piotr F. Krzych, Łukasz J. Int J Mol Sci Case Report Despite efforts to improve treatment outcomes, mortality in septic shock remains high. In some patients, despite the use of several adrenergic drugs, features of refractory vasoplegic shock with progressive multiorgan failure are observed. We present a case report of the successful reversal of vasoplegic shock following the use of methylene blue, a selective inhibitor of the inducible form of nitric oxide synthase, which prevents vasodilation in response to inflammatory cytokines. We also briefly review the literature. MDPI 2023-06-28 /pmc/articles/PMC10342053/ /pubmed/37445952 http://dx.doi.org/10.3390/ijms241310772 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Pluta, Michał P.
Putowski, Zbigniew
Czempik, Piotr F.
Krzych, Łukasz J.
Successful Use of Methylene Blue in Catecholamine-Resistant Septic Shock: A Case Report and Short Literature Review
title Successful Use of Methylene Blue in Catecholamine-Resistant Septic Shock: A Case Report and Short Literature Review
title_full Successful Use of Methylene Blue in Catecholamine-Resistant Septic Shock: A Case Report and Short Literature Review
title_fullStr Successful Use of Methylene Blue in Catecholamine-Resistant Septic Shock: A Case Report and Short Literature Review
title_full_unstemmed Successful Use of Methylene Blue in Catecholamine-Resistant Septic Shock: A Case Report and Short Literature Review
title_short Successful Use of Methylene Blue in Catecholamine-Resistant Septic Shock: A Case Report and Short Literature Review
title_sort successful use of methylene blue in catecholamine-resistant septic shock: a case report and short literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342053/
https://www.ncbi.nlm.nih.gov/pubmed/37445952
http://dx.doi.org/10.3390/ijms241310772
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