Tumor Site-Specific Cleavage Improves the Antitumor Efficacy of Antibody–Drug Conjugates

Antibody—drug conjugates (ADCs) play important roles in tumor therapy. However, traditional ADCs are limited by the extremely large molecular weight of the antibody molecules, which results in low permeability into solid tumors. The use of small ADCs may be expected to alleviate this problem, but th...

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Detalles Bibliográficos
Autores principales: Xu, Keyuan, Han, Jiani, Yang, Liu, Cao, Li, Li, Shuang, Hong, Zhangyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342105/
https://www.ncbi.nlm.nih.gov/pubmed/37446189
http://dx.doi.org/10.3390/ijms241311011

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