Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models

Macrophage infiltration and accumulation is a hallmark of chronic kidney disease. Tissue plasminogen activator (tPA) is a serine protease regulating the homeostasis of blood coagulation, fibrinolysis, and matrix degradation, and has been shown to act as a cytokine to trigger various receptor-mediate...

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Detalles Bibliográficos
Autores principales: Lin, Ling, Hu, Kebin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342253/
https://www.ncbi.nlm.nih.gov/pubmed/37446244
http://dx.doi.org/10.3390/ijms241311067
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author Lin, Ling
Hu, Kebin
author_facet Lin, Ling
Hu, Kebin
author_sort Lin, Ling
collection PubMed
description Macrophage infiltration and accumulation is a hallmark of chronic kidney disease. Tissue plasminogen activator (tPA) is a serine protease regulating the homeostasis of blood coagulation, fibrinolysis, and matrix degradation, and has been shown to act as a cytokine to trigger various receptor-mediated intracellular signal pathways, modulating macrophage function in response to kidney injury. In this review, we discuss the current understanding of tPA-modulated macrophage function and underlying signaling mechanisms during kidney fibrosis and inflammation.
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spelling pubmed-103422532023-07-14 Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models Lin, Ling Hu, Kebin Int J Mol Sci Review Macrophage infiltration and accumulation is a hallmark of chronic kidney disease. Tissue plasminogen activator (tPA) is a serine protease regulating the homeostasis of blood coagulation, fibrinolysis, and matrix degradation, and has been shown to act as a cytokine to trigger various receptor-mediated intracellular signal pathways, modulating macrophage function in response to kidney injury. In this review, we discuss the current understanding of tPA-modulated macrophage function and underlying signaling mechanisms during kidney fibrosis and inflammation. MDPI 2023-07-04 /pmc/articles/PMC10342253/ /pubmed/37446244 http://dx.doi.org/10.3390/ijms241311067 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lin, Ling
Hu, Kebin
Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models
title Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models
title_full Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models
title_fullStr Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models
title_full_unstemmed Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models
title_short Macrophage Function Modulated by tPA Signaling in Mouse Experimental Kidney Disease Models
title_sort macrophage function modulated by tpa signaling in mouse experimental kidney disease models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342253/
https://www.ncbi.nlm.nih.gov/pubmed/37446244
http://dx.doi.org/10.3390/ijms241311067
work_keys_str_mv AT linling macrophagefunctionmodulatedbytpasignalinginmouseexperimentalkidneydiseasemodels
AT hukebin macrophagefunctionmodulatedbytpasignalinginmouseexperimentalkidneydiseasemodels

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