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From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example

The Australian rainforest is a rich source of medicinal plants that have evolved in the face of dramatic environmental challenges over a million years due to its prolonged geographical isolation from other continents. The rainforest consists of an inherent richness of plant secondary metabolites tha...

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Autores principales: Kumar, Payaal, Mathew, Shintu, Gamage, Rashmi, Bodkin, Frances, Doyle, Kerrie, Rossetti, Ilaria, Wagnon, Ingrid, Zhou, Xian, Raju, Ritesh, Gyengesi, Erika, Münch, Gerald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342267/
https://www.ncbi.nlm.nih.gov/pubmed/37446262
http://dx.doi.org/10.3390/ijms241311086
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author Kumar, Payaal
Mathew, Shintu
Gamage, Rashmi
Bodkin, Frances
Doyle, Kerrie
Rossetti, Ilaria
Wagnon, Ingrid
Zhou, Xian
Raju, Ritesh
Gyengesi, Erika
Münch, Gerald
author_facet Kumar, Payaal
Mathew, Shintu
Gamage, Rashmi
Bodkin, Frances
Doyle, Kerrie
Rossetti, Ilaria
Wagnon, Ingrid
Zhou, Xian
Raju, Ritesh
Gyengesi, Erika
Münch, Gerald
author_sort Kumar, Payaal
collection PubMed
description The Australian rainforest is a rich source of medicinal plants that have evolved in the face of dramatic environmental challenges over a million years due to its prolonged geographical isolation from other continents. The rainforest consists of an inherent richness of plant secondary metabolites that are the most intense in the rainforest. The search for more potent and more bioavailable compounds from other plant sources is ongoing, and our short review will outline the pathways from the discovery of bioactive plants to the structural identification of active compounds, testing for potency, and then neuroprotection in a triculture system, and finally, the validation in an appropriate neuro-inflammatory mouse model, using some examples from our current research. We will focus on neuroinflammation as a potential treatment target for neurodegenerative diseases including multiple sclerosis (MS), Parkinson’s (PD), and Alzheimer’s disease (AD) for these plant-derived, anti-inflammatory molecules and highlight cytokine suppressive anti-inflammatory drugs (CSAIDs) as a better alternative to conventional nonsteroidal anti-inflammatory drugs (NSAIDs) to treat neuroinflammatory disorders.
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spelling pubmed-103422672023-07-14 From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example Kumar, Payaal Mathew, Shintu Gamage, Rashmi Bodkin, Frances Doyle, Kerrie Rossetti, Ilaria Wagnon, Ingrid Zhou, Xian Raju, Ritesh Gyengesi, Erika Münch, Gerald Int J Mol Sci Review The Australian rainforest is a rich source of medicinal plants that have evolved in the face of dramatic environmental challenges over a million years due to its prolonged geographical isolation from other continents. The rainforest consists of an inherent richness of plant secondary metabolites that are the most intense in the rainforest. The search for more potent and more bioavailable compounds from other plant sources is ongoing, and our short review will outline the pathways from the discovery of bioactive plants to the structural identification of active compounds, testing for potency, and then neuroprotection in a triculture system, and finally, the validation in an appropriate neuro-inflammatory mouse model, using some examples from our current research. We will focus on neuroinflammation as a potential treatment target for neurodegenerative diseases including multiple sclerosis (MS), Parkinson’s (PD), and Alzheimer’s disease (AD) for these plant-derived, anti-inflammatory molecules and highlight cytokine suppressive anti-inflammatory drugs (CSAIDs) as a better alternative to conventional nonsteroidal anti-inflammatory drugs (NSAIDs) to treat neuroinflammatory disorders. MDPI 2023-07-04 /pmc/articles/PMC10342267/ /pubmed/37446262 http://dx.doi.org/10.3390/ijms241311086 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kumar, Payaal
Mathew, Shintu
Gamage, Rashmi
Bodkin, Frances
Doyle, Kerrie
Rossetti, Ilaria
Wagnon, Ingrid
Zhou, Xian
Raju, Ritesh
Gyengesi, Erika
Münch, Gerald
From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example
title From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example
title_full From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example
title_fullStr From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example
title_full_unstemmed From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example
title_short From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example
title_sort from the bush to the brain: preclinical stages of ethnobotanical anti-inflammatory and neuroprotective drug discovery—an australian example
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342267/
https://www.ncbi.nlm.nih.gov/pubmed/37446262
http://dx.doi.org/10.3390/ijms241311086
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