Cargando…
From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example
The Australian rainforest is a rich source of medicinal plants that have evolved in the face of dramatic environmental challenges over a million years due to its prolonged geographical isolation from other continents. The rainforest consists of an inherent richness of plant secondary metabolites tha...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342267/ https://www.ncbi.nlm.nih.gov/pubmed/37446262 http://dx.doi.org/10.3390/ijms241311086 |
_version_ | 1785072458384015360 |
---|---|
author | Kumar, Payaal Mathew, Shintu Gamage, Rashmi Bodkin, Frances Doyle, Kerrie Rossetti, Ilaria Wagnon, Ingrid Zhou, Xian Raju, Ritesh Gyengesi, Erika Münch, Gerald |
author_facet | Kumar, Payaal Mathew, Shintu Gamage, Rashmi Bodkin, Frances Doyle, Kerrie Rossetti, Ilaria Wagnon, Ingrid Zhou, Xian Raju, Ritesh Gyengesi, Erika Münch, Gerald |
author_sort | Kumar, Payaal |
collection | PubMed |
description | The Australian rainforest is a rich source of medicinal plants that have evolved in the face of dramatic environmental challenges over a million years due to its prolonged geographical isolation from other continents. The rainforest consists of an inherent richness of plant secondary metabolites that are the most intense in the rainforest. The search for more potent and more bioavailable compounds from other plant sources is ongoing, and our short review will outline the pathways from the discovery of bioactive plants to the structural identification of active compounds, testing for potency, and then neuroprotection in a triculture system, and finally, the validation in an appropriate neuro-inflammatory mouse model, using some examples from our current research. We will focus on neuroinflammation as a potential treatment target for neurodegenerative diseases including multiple sclerosis (MS), Parkinson’s (PD), and Alzheimer’s disease (AD) for these plant-derived, anti-inflammatory molecules and highlight cytokine suppressive anti-inflammatory drugs (CSAIDs) as a better alternative to conventional nonsteroidal anti-inflammatory drugs (NSAIDs) to treat neuroinflammatory disorders. |
format | Online Article Text |
id | pubmed-10342267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103422672023-07-14 From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example Kumar, Payaal Mathew, Shintu Gamage, Rashmi Bodkin, Frances Doyle, Kerrie Rossetti, Ilaria Wagnon, Ingrid Zhou, Xian Raju, Ritesh Gyengesi, Erika Münch, Gerald Int J Mol Sci Review The Australian rainforest is a rich source of medicinal plants that have evolved in the face of dramatic environmental challenges over a million years due to its prolonged geographical isolation from other continents. The rainforest consists of an inherent richness of plant secondary metabolites that are the most intense in the rainforest. The search for more potent and more bioavailable compounds from other plant sources is ongoing, and our short review will outline the pathways from the discovery of bioactive plants to the structural identification of active compounds, testing for potency, and then neuroprotection in a triculture system, and finally, the validation in an appropriate neuro-inflammatory mouse model, using some examples from our current research. We will focus on neuroinflammation as a potential treatment target for neurodegenerative diseases including multiple sclerosis (MS), Parkinson’s (PD), and Alzheimer’s disease (AD) for these plant-derived, anti-inflammatory molecules and highlight cytokine suppressive anti-inflammatory drugs (CSAIDs) as a better alternative to conventional nonsteroidal anti-inflammatory drugs (NSAIDs) to treat neuroinflammatory disorders. MDPI 2023-07-04 /pmc/articles/PMC10342267/ /pubmed/37446262 http://dx.doi.org/10.3390/ijms241311086 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kumar, Payaal Mathew, Shintu Gamage, Rashmi Bodkin, Frances Doyle, Kerrie Rossetti, Ilaria Wagnon, Ingrid Zhou, Xian Raju, Ritesh Gyengesi, Erika Münch, Gerald From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example |
title | From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example |
title_full | From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example |
title_fullStr | From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example |
title_full_unstemmed | From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example |
title_short | From the Bush to the Brain: Preclinical Stages of Ethnobotanical Anti-Inflammatory and Neuroprotective Drug Discovery—An Australian Example |
title_sort | from the bush to the brain: preclinical stages of ethnobotanical anti-inflammatory and neuroprotective drug discovery—an australian example |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342267/ https://www.ncbi.nlm.nih.gov/pubmed/37446262 http://dx.doi.org/10.3390/ijms241311086 |
work_keys_str_mv | AT kumarpayaal fromthebushtothebrainpreclinicalstagesofethnobotanicalantiinflammatoryandneuroprotectivedrugdiscoveryanaustralianexample AT mathewshintu fromthebushtothebrainpreclinicalstagesofethnobotanicalantiinflammatoryandneuroprotectivedrugdiscoveryanaustralianexample AT gamagerashmi fromthebushtothebrainpreclinicalstagesofethnobotanicalantiinflammatoryandneuroprotectivedrugdiscoveryanaustralianexample AT bodkinfrances fromthebushtothebrainpreclinicalstagesofethnobotanicalantiinflammatoryandneuroprotectivedrugdiscoveryanaustralianexample AT doylekerrie fromthebushtothebrainpreclinicalstagesofethnobotanicalantiinflammatoryandneuroprotectivedrugdiscoveryanaustralianexample AT rossettiilaria fromthebushtothebrainpreclinicalstagesofethnobotanicalantiinflammatoryandneuroprotectivedrugdiscoveryanaustralianexample AT wagnoningrid fromthebushtothebrainpreclinicalstagesofethnobotanicalantiinflammatoryandneuroprotectivedrugdiscoveryanaustralianexample AT zhouxian fromthebushtothebrainpreclinicalstagesofethnobotanicalantiinflammatoryandneuroprotectivedrugdiscoveryanaustralianexample AT rajuritesh fromthebushtothebrainpreclinicalstagesofethnobotanicalantiinflammatoryandneuroprotectivedrugdiscoveryanaustralianexample AT gyengesierika fromthebushtothebrainpreclinicalstagesofethnobotanicalantiinflammatoryandneuroprotectivedrugdiscoveryanaustralianexample AT munchgerald fromthebushtothebrainpreclinicalstagesofethnobotanicalantiinflammatoryandneuroprotectivedrugdiscoveryanaustralianexample |