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Clinical and Biological Predictors of Cancer Incidence and Mortality in Patients with Stable Coronary Artery Disease

Clinical and epidemiological evidence has recently revealed a link between coronary artery disease (CAD) and cancer. Shared risk factors and common biological pathways are probably involved in both pathological conditions. The aim of this paper was to evaluate whether and which conventional risk fac...

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Autores principales: Campolo, Jonica, Borghini, Andrea, Parolini, Marina, Mercuri, Antonella, Turchi, Stefano, Andreassi, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342270/
https://www.ncbi.nlm.nih.gov/pubmed/37446269
http://dx.doi.org/10.3390/ijms241311091
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author Campolo, Jonica
Borghini, Andrea
Parolini, Marina
Mercuri, Antonella
Turchi, Stefano
Andreassi, Maria Grazia
author_facet Campolo, Jonica
Borghini, Andrea
Parolini, Marina
Mercuri, Antonella
Turchi, Stefano
Andreassi, Maria Grazia
author_sort Campolo, Jonica
collection PubMed
description Clinical and epidemiological evidence has recently revealed a link between coronary artery disease (CAD) and cancer. Shared risk factors and common biological pathways are probably involved in both pathological conditions. The aim of this paper was to evaluate whether and which conventional risk factors and novel circulating biomarkers could predict cancer incidence and death in patients with CAD. The study included 750 CAD patients, who underwent blood sampling for the evaluation of systemic inflammatory indexes (NLR and SII) and specific biomarkers of oxidative damage (leukocyte telomere length (LTL), mitochondrial DNA copy number (mtDNAcn)). Study participants were followed up for a mean of 5.4 ± 1.2 years. Sixty-seven patients (8.9%) developed cancer during the follow-up time, and nineteen (2.5%) died of cancer. Cox multivariable analysis revealed that age (HR = 1.071; 95% CI: 1.034–1.109; p < 0.001), smoking habit (HR = 1.994; 95% CI: 1.140–3.488; p = 0.016), obesity (HR = 1.708; 95% CI: 1.022–2.854; p = 0.041) and SII (HR = 1.002; 95% CI: 1.001–1.003; p = 0.045) were associated with cancer incidence, while only age (HR = 1.132; 95% CI: 1.052–1.219; p = 0.001) was a predictor of cancer death. Patients with lung and gastrointestinal cancers had significantly higher median mtDNAcn levels than those without cancer. Our study suggests that aggressive risk factor modification and suppression of chronic inflammation may be essential to preventing cancer in CAD patients.
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spelling pubmed-103422702023-07-14 Clinical and Biological Predictors of Cancer Incidence and Mortality in Patients with Stable Coronary Artery Disease Campolo, Jonica Borghini, Andrea Parolini, Marina Mercuri, Antonella Turchi, Stefano Andreassi, Maria Grazia Int J Mol Sci Article Clinical and epidemiological evidence has recently revealed a link between coronary artery disease (CAD) and cancer. Shared risk factors and common biological pathways are probably involved in both pathological conditions. The aim of this paper was to evaluate whether and which conventional risk factors and novel circulating biomarkers could predict cancer incidence and death in patients with CAD. The study included 750 CAD patients, who underwent blood sampling for the evaluation of systemic inflammatory indexes (NLR and SII) and specific biomarkers of oxidative damage (leukocyte telomere length (LTL), mitochondrial DNA copy number (mtDNAcn)). Study participants were followed up for a mean of 5.4 ± 1.2 years. Sixty-seven patients (8.9%) developed cancer during the follow-up time, and nineteen (2.5%) died of cancer. Cox multivariable analysis revealed that age (HR = 1.071; 95% CI: 1.034–1.109; p < 0.001), smoking habit (HR = 1.994; 95% CI: 1.140–3.488; p = 0.016), obesity (HR = 1.708; 95% CI: 1.022–2.854; p = 0.041) and SII (HR = 1.002; 95% CI: 1.001–1.003; p = 0.045) were associated with cancer incidence, while only age (HR = 1.132; 95% CI: 1.052–1.219; p = 0.001) was a predictor of cancer death. Patients with lung and gastrointestinal cancers had significantly higher median mtDNAcn levels than those without cancer. Our study suggests that aggressive risk factor modification and suppression of chronic inflammation may be essential to preventing cancer in CAD patients. MDPI 2023-07-04 /pmc/articles/PMC10342270/ /pubmed/37446269 http://dx.doi.org/10.3390/ijms241311091 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Campolo, Jonica
Borghini, Andrea
Parolini, Marina
Mercuri, Antonella
Turchi, Stefano
Andreassi, Maria Grazia
Clinical and Biological Predictors of Cancer Incidence and Mortality in Patients with Stable Coronary Artery Disease
title Clinical and Biological Predictors of Cancer Incidence and Mortality in Patients with Stable Coronary Artery Disease
title_full Clinical and Biological Predictors of Cancer Incidence and Mortality in Patients with Stable Coronary Artery Disease
title_fullStr Clinical and Biological Predictors of Cancer Incidence and Mortality in Patients with Stable Coronary Artery Disease
title_full_unstemmed Clinical and Biological Predictors of Cancer Incidence and Mortality in Patients with Stable Coronary Artery Disease
title_short Clinical and Biological Predictors of Cancer Incidence and Mortality in Patients with Stable Coronary Artery Disease
title_sort clinical and biological predictors of cancer incidence and mortality in patients with stable coronary artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342270/
https://www.ncbi.nlm.nih.gov/pubmed/37446269
http://dx.doi.org/10.3390/ijms241311091
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