Identification of N-Acyl Hydrazones as New Non-Zinc-Binding MMP-13 Inhibitors by Structure-Based Virtual Screening Studies and Chemical Optimization

Matrix metalloproteinase 13 plays a central role in osteoarthritis (OA), as its overexpression induces an excessive breakdown of collagen that results in an imbalance between collagen synthesis and degradation in the joint, leading to progressive articular cartilage degradation. Therefore, MMP-13 ha...

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Detalles Bibliográficos
Autores principales: Cuffaro, Doretta, Gimeno, Aleix, Bernardoni, Bianca Laura, Di Leo, Riccardo, Pujadas, Gerard, Garcia-Vallvé, Santiago, Nencetti, Susanna, Rossello, Armando, Nuti, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342305/
https://www.ncbi.nlm.nih.gov/pubmed/37446276
http://dx.doi.org/10.3390/ijms241311098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342305/
https://www.ncbi.nlm.nih.gov/pubmed/37446276
http://dx.doi.org/10.3390/ijms241311098

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