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Antipsychotic Use and Mortality in Persons with Alcohol-Related Dementia or Wernicke–Korsakoff Syndrome: A Nationwide Register Study in Finland

Background: Research on the use of psychotropic drugs in people with alcohol-related neurocognitive disorders is virtually nonexistent. We examined the prevalence of antipsychotic drug use and its effect on mortality among patients with Wernicke–Korsakoff syndrome (WKS) or alcohol-related dementia (...

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Autores principales: Palm, Anniina, Talaslahti, Tiina, Vataja, Risto, Ginters, Milena, Kautiainen, Hannu, Elonheimo, Henrik, Suvisaari, Jaana, Lindberg, Nina, Koponen, Hannu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342345/
https://www.ncbi.nlm.nih.gov/pubmed/37445298
http://dx.doi.org/10.3390/jcm12134263
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author Palm, Anniina
Talaslahti, Tiina
Vataja, Risto
Ginters, Milena
Kautiainen, Hannu
Elonheimo, Henrik
Suvisaari, Jaana
Lindberg, Nina
Koponen, Hannu
author_facet Palm, Anniina
Talaslahti, Tiina
Vataja, Risto
Ginters, Milena
Kautiainen, Hannu
Elonheimo, Henrik
Suvisaari, Jaana
Lindberg, Nina
Koponen, Hannu
author_sort Palm, Anniina
collection PubMed
description Background: Research on the use of psychotropic drugs in people with alcohol-related neurocognitive disorders is virtually nonexistent. We examined the prevalence of antipsychotic drug use and its effect on mortality among patients with Wernicke–Korsakoff syndrome (WKS) or alcohol-related dementia (ARD). Methods: In this nationwide register study, we collected data on the medication use and mortality of all persons aged ≥40 diagnosed with WKS (n = 1149) or ARD (n = 2432) between 1998 and 2015 in Finland. We calculated the prevalence of antipsychotic use within one year of diagnosis and the adjusted cumulative mortality of antipsychotic users versus non-users in relation to the age-, sex-, and calendar year-matched general population. Results: Of the WKS and ARD patients, 35.9% and 38.5%, respectively, purchased one or more antipsychotic drugs in the year following diagnosis. The adjusted cumulative mortality of the antipsychotic users was significantly lower than that of non-users in both the WKS and ARD groups, where the adjusted hazard ratios (95% CI) were 0.85 (0.72–0.99) and 0.73 (0.65–0.81), respectively. WKS and ARD patients using antipsychotics were less likely to die of alcohol-related causes than antipsychotic non-users, but the difference was significant only in the ARD group. Conclusions: This population-based study shows that antipsychotic use is common in patients with WKS or ARD. In contrast to other dementia studies, our results indicate that the mortality of antipsychotic users is significantly lower than that of non-users. The lower mortality could be explained by decreased alcohol use and better healthcare coverage in antipsychotic users.
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spelling pubmed-103423452023-07-14 Antipsychotic Use and Mortality in Persons with Alcohol-Related Dementia or Wernicke–Korsakoff Syndrome: A Nationwide Register Study in Finland Palm, Anniina Talaslahti, Tiina Vataja, Risto Ginters, Milena Kautiainen, Hannu Elonheimo, Henrik Suvisaari, Jaana Lindberg, Nina Koponen, Hannu J Clin Med Article Background: Research on the use of psychotropic drugs in people with alcohol-related neurocognitive disorders is virtually nonexistent. We examined the prevalence of antipsychotic drug use and its effect on mortality among patients with Wernicke–Korsakoff syndrome (WKS) or alcohol-related dementia (ARD). Methods: In this nationwide register study, we collected data on the medication use and mortality of all persons aged ≥40 diagnosed with WKS (n = 1149) or ARD (n = 2432) between 1998 and 2015 in Finland. We calculated the prevalence of antipsychotic use within one year of diagnosis and the adjusted cumulative mortality of antipsychotic users versus non-users in relation to the age-, sex-, and calendar year-matched general population. Results: Of the WKS and ARD patients, 35.9% and 38.5%, respectively, purchased one or more antipsychotic drugs in the year following diagnosis. The adjusted cumulative mortality of the antipsychotic users was significantly lower than that of non-users in both the WKS and ARD groups, where the adjusted hazard ratios (95% CI) were 0.85 (0.72–0.99) and 0.73 (0.65–0.81), respectively. WKS and ARD patients using antipsychotics were less likely to die of alcohol-related causes than antipsychotic non-users, but the difference was significant only in the ARD group. Conclusions: This population-based study shows that antipsychotic use is common in patients with WKS or ARD. In contrast to other dementia studies, our results indicate that the mortality of antipsychotic users is significantly lower than that of non-users. The lower mortality could be explained by decreased alcohol use and better healthcare coverage in antipsychotic users. MDPI 2023-06-25 /pmc/articles/PMC10342345/ /pubmed/37445298 http://dx.doi.org/10.3390/jcm12134263 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Palm, Anniina
Talaslahti, Tiina
Vataja, Risto
Ginters, Milena
Kautiainen, Hannu
Elonheimo, Henrik
Suvisaari, Jaana
Lindberg, Nina
Koponen, Hannu
Antipsychotic Use and Mortality in Persons with Alcohol-Related Dementia or Wernicke–Korsakoff Syndrome: A Nationwide Register Study in Finland
title Antipsychotic Use and Mortality in Persons with Alcohol-Related Dementia or Wernicke–Korsakoff Syndrome: A Nationwide Register Study in Finland
title_full Antipsychotic Use and Mortality in Persons with Alcohol-Related Dementia or Wernicke–Korsakoff Syndrome: A Nationwide Register Study in Finland
title_fullStr Antipsychotic Use and Mortality in Persons with Alcohol-Related Dementia or Wernicke–Korsakoff Syndrome: A Nationwide Register Study in Finland
title_full_unstemmed Antipsychotic Use and Mortality in Persons with Alcohol-Related Dementia or Wernicke–Korsakoff Syndrome: A Nationwide Register Study in Finland
title_short Antipsychotic Use and Mortality in Persons with Alcohol-Related Dementia or Wernicke–Korsakoff Syndrome: A Nationwide Register Study in Finland
title_sort antipsychotic use and mortality in persons with alcohol-related dementia or wernicke–korsakoff syndrome: a nationwide register study in finland
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342345/
https://www.ncbi.nlm.nih.gov/pubmed/37445298
http://dx.doi.org/10.3390/jcm12134263
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