Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy

This study investigates the long-term outcomes of clival chordoma patients treated with the endonasal transclival approach (ETCA) and early adjuvant radiation therapy. A retrospective review of 17 patients (2002–2013) showed a 10-year progression-free survival (PFS) rate of 67.4%, with the ETCA grou...

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Detalles Bibliográficos
Autores principales: Yoo, Hyun Dong, Chung, Jong Chul, Park, Ki Seok, Chung, Seung Young, Park, Moon Sun, Ryu, Seungjun, Kim, Seong Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342406/
https://www.ncbi.nlm.nih.gov/pubmed/37445495
http://dx.doi.org/10.3390/jcm12134460
Descripción
Sumario:This study investigates the long-term outcomes of clival chordoma patients treated with the endonasal transclival approach (ETCA) and early adjuvant radiation therapy. A retrospective review of 17 patients (2002–2013) showed a 10-year progression-free survival (PFS) rate of 67.4%, with the ETCA group showing fewer progressions and cranial neuropathies than those treated with combined approaches. The ETCA, a minimally invasive technique, provided a similar extent of resection compared to conventional skull-base approaches and enabled safe delivery of high-dose adjuvant radiotherapy. The findings suggest that ETCA is an effective treatment for centrally located clival chordomas.

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