Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy

This study investigates the long-term outcomes of clival chordoma patients treated with the endonasal transclival approach (ETCA) and early adjuvant radiation therapy. A retrospective review of 17 patients (2002–2013) showed a 10-year progression-free survival (PFS) rate of 67.4%, with the ETCA grou...

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Autores principales: Yoo, Hyun Dong, Chung, Jong Chul, Park, Ki Seok, Chung, Seung Young, Park, Moon Sun, Ryu, Seungjun, Kim, Seong Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342406/
https://www.ncbi.nlm.nih.gov/pubmed/37445495
http://dx.doi.org/10.3390/jcm12134460
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author Yoo, Hyun Dong
Chung, Jong Chul
Park, Ki Seok
Chung, Seung Young
Park, Moon Sun
Ryu, Seungjun
Kim, Seong Min
author_facet Yoo, Hyun Dong
Chung, Jong Chul
Park, Ki Seok
Chung, Seung Young
Park, Moon Sun
Ryu, Seungjun
Kim, Seong Min
author_sort Yoo, Hyun Dong
collection PubMed
description This study investigates the long-term outcomes of clival chordoma patients treated with the endonasal transclival approach (ETCA) and early adjuvant radiation therapy. A retrospective review of 17 patients (2002–2013) showed a 10-year progression-free survival (PFS) rate of 67.4%, with the ETCA group showing fewer progressions and cranial neuropathies than those treated with combined approaches. The ETCA, a minimally invasive technique, provided a similar extent of resection compared to conventional skull-base approaches and enabled safe delivery of high-dose adjuvant radiotherapy. The findings suggest that ETCA is an effective treatment for centrally located clival chordomas.
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spelling pubmed-103424062023-07-14 Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy Yoo, Hyun Dong Chung, Jong Chul Park, Ki Seok Chung, Seung Young Park, Moon Sun Ryu, Seungjun Kim, Seong Min J Clin Med Article This study investigates the long-term outcomes of clival chordoma patients treated with the endonasal transclival approach (ETCA) and early adjuvant radiation therapy. A retrospective review of 17 patients (2002–2013) showed a 10-year progression-free survival (PFS) rate of 67.4%, with the ETCA group showing fewer progressions and cranial neuropathies than those treated with combined approaches. The ETCA, a minimally invasive technique, provided a similar extent of resection compared to conventional skull-base approaches and enabled safe delivery of high-dose adjuvant radiotherapy. The findings suggest that ETCA is an effective treatment for centrally located clival chordomas. MDPI 2023-07-03 /pmc/articles/PMC10342406/ /pubmed/37445495 http://dx.doi.org/10.3390/jcm12134460 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoo, Hyun Dong
Chung, Jong Chul
Park, Ki Seok
Chung, Seung Young
Park, Moon Sun
Ryu, Seungjun
Kim, Seong Min
Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy
title Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy
title_full Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy
title_fullStr Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy
title_full_unstemmed Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy
title_short Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy
title_sort long-term outcomes after multimodal treatment for clival chordoma: efficacy of the endonasal transclival approach with early adjuvant radiation therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342406/
https://www.ncbi.nlm.nih.gov/pubmed/37445495
http://dx.doi.org/10.3390/jcm12134460
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