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Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management

Background and aims: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe. Methods: The European Registry on the management of Helicobacter py...

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Autores principales: García-Morales, Natalia, Pérez-Aísa, Ángeles, Fiorini, Giulia, Tepes, Bojan, Castro-Fernández, Manuel, Lucendo, Alfredo, Voynovan, Irina, Bujanda, Luis, Garre, Ana, Rodrigo, Luis, Martínez Domínguez, Samuel Jesús, Denkovski, Maja, Huguet Malavés, Jose M., Jonaitis, Laimas, Bumane, Renate, Zaytsev, Oleg, Mata Romero, Pilar, Barrio, Jesús, Fernández-Salazar, Luis, Sarsenbaeva, Aiman Silkanovna, Ortiz Polo, Inmaculada, Alekseenko, Sergey, Saracino, Ilaria Maria, Vaira, Dino, Keco-Huerga, Alma, Bordin, Dmitry, Gasbarrini, Antonio, Lerang, Frode, Rokkas, Theodore, Kupčinskas, Juozas, Leja, Marcis, Babayeva, Gulustan, Marcos Pinto, Ricardo, Tonkić, Ante, Smith, Sinead, Phull, Perminder, Buzas, Gyorgy M., Simsek, Halis, Boltin, Doron, Gridnyev, Oleksiy, Venerito, Marino, Milivojevic, Vladimir, Torà, Núria, Cano-Català, Anna, Moreira, Leticia, Nyssen, Olga P., Mégraud, Francis, O’Morain, Colm, Gisbert, Javier P., Puig, Ignasi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342434/
https://www.ncbi.nlm.nih.gov/pubmed/37445399
http://dx.doi.org/10.3390/jcm12134363
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author García-Morales, Natalia
Pérez-Aísa, Ángeles
Fiorini, Giulia
Tepes, Bojan
Castro-Fernández, Manuel
Lucendo, Alfredo
Voynovan, Irina
Bujanda, Luis
Garre, Ana
Rodrigo, Luis
Martínez Domínguez, Samuel Jesús
Denkovski, Maja
Huguet Malavés, Jose M.
Jonaitis, Laimas
Bumane, Renate
Zaytsev, Oleg
Mata Romero, Pilar
Barrio, Jesús
Fernández-Salazar, Luis
Sarsenbaeva, Aiman Silkanovna
Ortiz Polo, Inmaculada
Alekseenko, Sergey
Saracino, Ilaria Maria
Vaira, Dino
Keco-Huerga, Alma
Bordin, Dmitry
Gasbarrini, Antonio
Lerang, Frode
Rokkas, Theodore
Kupčinskas, Juozas
Leja, Marcis
Babayeva, Gulustan
Marcos Pinto, Ricardo
Tonkić, Ante
Smith, Sinead
Phull, Perminder
Buzas, Gyorgy M.
Simsek, Halis
Boltin, Doron
Gridnyev, Oleksiy
Venerito, Marino
Milivojevic, Vladimir
Torà, Núria
Cano-Català, Anna
Moreira, Leticia
Nyssen, Olga P.
Mégraud, Francis
O’Morain, Colm
Gisbert, Javier P.
Puig, Ignasi
author_facet García-Morales, Natalia
Pérez-Aísa, Ángeles
Fiorini, Giulia
Tepes, Bojan
Castro-Fernández, Manuel
Lucendo, Alfredo
Voynovan, Irina
Bujanda, Luis
Garre, Ana
Rodrigo, Luis
Martínez Domínguez, Samuel Jesús
Denkovski, Maja
Huguet Malavés, Jose M.
Jonaitis, Laimas
Bumane, Renate
Zaytsev, Oleg
Mata Romero, Pilar
Barrio, Jesús
Fernández-Salazar, Luis
Sarsenbaeva, Aiman Silkanovna
Ortiz Polo, Inmaculada
Alekseenko, Sergey
Saracino, Ilaria Maria
Vaira, Dino
Keco-Huerga, Alma
Bordin, Dmitry
Gasbarrini, Antonio
Lerang, Frode
Rokkas, Theodore
Kupčinskas, Juozas
Leja, Marcis
Babayeva, Gulustan
Marcos Pinto, Ricardo
Tonkić, Ante
Smith, Sinead
Phull, Perminder
Buzas, Gyorgy M.
Simsek, Halis
Boltin, Doron
Gridnyev, Oleksiy
Venerito, Marino
Milivojevic, Vladimir
Torà, Núria
Cano-Català, Anna
Moreira, Leticia
Nyssen, Olga P.
Mégraud, Francis
O’Morain, Colm
Gisbert, Javier P.
Puig, Ignasi
author_sort García-Morales, Natalia
collection PubMed
description Background and aims: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe. Methods: The European Registry on the management of Helicobacter pylori infection is an international, multicentre, prospective, non-interventional registry aiming to evaluate the management of Helicobacter pylori-infected patients in Europe. Countries with at least 100 cases registered from June 2013 to April 2021, and with a validated diagnostic method were analysed. Data were quality reviewed. Results: A total of 34,920 adult patients from 20 countries were included (mean age 51 years; 61% women). To establish the initial diagnosis, invasive tests were performed in 19,801 (71%) patients, non-invasive in 11,369 (41%), and both in 3437 (12%). The most frequent were histology (n = 11,885; 43%), a rapid urease test (n = 10,636; 38%) and an urea breath test (n = 7577; 27%). According to the age, invasive tests were indicated in 11,179 (77%) ≥50 years, and in 8603 (65%) <50 years. Depending on the country, the use of invasive tests ranged from 29–99% in <50 years to 60–99% in ≥50. Most of the tests used to confirm eradication were non-invasive (n = 32,540; 93%), with the urea breath test being the most frequent (n = 32,540; 78%). In 2983 (9%) post-treatment tests, histology (n = 1887; 5%) or a rapid urease test (n = 1223; 4%) were performed. Conclusion: A great heterogeneity was observed for the initial diagnosis and confirmation of the eradication. The reasons for the apparent lack of adherence to the clinical guidelines should be further explored.
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spelling pubmed-103424342023-07-14 Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management García-Morales, Natalia Pérez-Aísa, Ángeles Fiorini, Giulia Tepes, Bojan Castro-Fernández, Manuel Lucendo, Alfredo Voynovan, Irina Bujanda, Luis Garre, Ana Rodrigo, Luis Martínez Domínguez, Samuel Jesús Denkovski, Maja Huguet Malavés, Jose M. Jonaitis, Laimas Bumane, Renate Zaytsev, Oleg Mata Romero, Pilar Barrio, Jesús Fernández-Salazar, Luis Sarsenbaeva, Aiman Silkanovna Ortiz Polo, Inmaculada Alekseenko, Sergey Saracino, Ilaria Maria Vaira, Dino Keco-Huerga, Alma Bordin, Dmitry Gasbarrini, Antonio Lerang, Frode Rokkas, Theodore Kupčinskas, Juozas Leja, Marcis Babayeva, Gulustan Marcos Pinto, Ricardo Tonkić, Ante Smith, Sinead Phull, Perminder Buzas, Gyorgy M. Simsek, Halis Boltin, Doron Gridnyev, Oleksiy Venerito, Marino Milivojevic, Vladimir Torà, Núria Cano-Català, Anna Moreira, Leticia Nyssen, Olga P. Mégraud, Francis O’Morain, Colm Gisbert, Javier P. Puig, Ignasi J Clin Med Article Background and aims: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe. Methods: The European Registry on the management of Helicobacter pylori infection is an international, multicentre, prospective, non-interventional registry aiming to evaluate the management of Helicobacter pylori-infected patients in Europe. Countries with at least 100 cases registered from June 2013 to April 2021, and with a validated diagnostic method were analysed. Data were quality reviewed. Results: A total of 34,920 adult patients from 20 countries were included (mean age 51 years; 61% women). To establish the initial diagnosis, invasive tests were performed in 19,801 (71%) patients, non-invasive in 11,369 (41%), and both in 3437 (12%). The most frequent were histology (n = 11,885; 43%), a rapid urease test (n = 10,636; 38%) and an urea breath test (n = 7577; 27%). According to the age, invasive tests were indicated in 11,179 (77%) ≥50 years, and in 8603 (65%) <50 years. Depending on the country, the use of invasive tests ranged from 29–99% in <50 years to 60–99% in ≥50. Most of the tests used to confirm eradication were non-invasive (n = 32,540; 93%), with the urea breath test being the most frequent (n = 32,540; 78%). In 2983 (9%) post-treatment tests, histology (n = 1887; 5%) or a rapid urease test (n = 1223; 4%) were performed. Conclusion: A great heterogeneity was observed for the initial diagnosis and confirmation of the eradication. The reasons for the apparent lack of adherence to the clinical guidelines should be further explored. MDPI 2023-06-28 /pmc/articles/PMC10342434/ /pubmed/37445399 http://dx.doi.org/10.3390/jcm12134363 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
García-Morales, Natalia
Pérez-Aísa, Ángeles
Fiorini, Giulia
Tepes, Bojan
Castro-Fernández, Manuel
Lucendo, Alfredo
Voynovan, Irina
Bujanda, Luis
Garre, Ana
Rodrigo, Luis
Martínez Domínguez, Samuel Jesús
Denkovski, Maja
Huguet Malavés, Jose M.
Jonaitis, Laimas
Bumane, Renate
Zaytsev, Oleg
Mata Romero, Pilar
Barrio, Jesús
Fernández-Salazar, Luis
Sarsenbaeva, Aiman Silkanovna
Ortiz Polo, Inmaculada
Alekseenko, Sergey
Saracino, Ilaria Maria
Vaira, Dino
Keco-Huerga, Alma
Bordin, Dmitry
Gasbarrini, Antonio
Lerang, Frode
Rokkas, Theodore
Kupčinskas, Juozas
Leja, Marcis
Babayeva, Gulustan
Marcos Pinto, Ricardo
Tonkić, Ante
Smith, Sinead
Phull, Perminder
Buzas, Gyorgy M.
Simsek, Halis
Boltin, Doron
Gridnyev, Oleksiy
Venerito, Marino
Milivojevic, Vladimir
Torà, Núria
Cano-Català, Anna
Moreira, Leticia
Nyssen, Olga P.
Mégraud, Francis
O’Morain, Colm
Gisbert, Javier P.
Puig, Ignasi
Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management
title Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management
title_full Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management
title_fullStr Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management
title_full_unstemmed Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management
title_short Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management
title_sort helicobacter pylori diagnostic tests used in europe: results of over 34,000 patients from the european registry on helicobacter pylori management
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342434/
https://www.ncbi.nlm.nih.gov/pubmed/37445399
http://dx.doi.org/10.3390/jcm12134363
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