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Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management
Background and aims: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe. Methods: The European Registry on the management of Helicobacter py...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342434/ https://www.ncbi.nlm.nih.gov/pubmed/37445399 http://dx.doi.org/10.3390/jcm12134363 |
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author | García-Morales, Natalia Pérez-Aísa, Ángeles Fiorini, Giulia Tepes, Bojan Castro-Fernández, Manuel Lucendo, Alfredo Voynovan, Irina Bujanda, Luis Garre, Ana Rodrigo, Luis Martínez Domínguez, Samuel Jesús Denkovski, Maja Huguet Malavés, Jose M. Jonaitis, Laimas Bumane, Renate Zaytsev, Oleg Mata Romero, Pilar Barrio, Jesús Fernández-Salazar, Luis Sarsenbaeva, Aiman Silkanovna Ortiz Polo, Inmaculada Alekseenko, Sergey Saracino, Ilaria Maria Vaira, Dino Keco-Huerga, Alma Bordin, Dmitry Gasbarrini, Antonio Lerang, Frode Rokkas, Theodore Kupčinskas, Juozas Leja, Marcis Babayeva, Gulustan Marcos Pinto, Ricardo Tonkić, Ante Smith, Sinead Phull, Perminder Buzas, Gyorgy M. Simsek, Halis Boltin, Doron Gridnyev, Oleksiy Venerito, Marino Milivojevic, Vladimir Torà, Núria Cano-Català, Anna Moreira, Leticia Nyssen, Olga P. Mégraud, Francis O’Morain, Colm Gisbert, Javier P. Puig, Ignasi |
author_facet | García-Morales, Natalia Pérez-Aísa, Ángeles Fiorini, Giulia Tepes, Bojan Castro-Fernández, Manuel Lucendo, Alfredo Voynovan, Irina Bujanda, Luis Garre, Ana Rodrigo, Luis Martínez Domínguez, Samuel Jesús Denkovski, Maja Huguet Malavés, Jose M. Jonaitis, Laimas Bumane, Renate Zaytsev, Oleg Mata Romero, Pilar Barrio, Jesús Fernández-Salazar, Luis Sarsenbaeva, Aiman Silkanovna Ortiz Polo, Inmaculada Alekseenko, Sergey Saracino, Ilaria Maria Vaira, Dino Keco-Huerga, Alma Bordin, Dmitry Gasbarrini, Antonio Lerang, Frode Rokkas, Theodore Kupčinskas, Juozas Leja, Marcis Babayeva, Gulustan Marcos Pinto, Ricardo Tonkić, Ante Smith, Sinead Phull, Perminder Buzas, Gyorgy M. Simsek, Halis Boltin, Doron Gridnyev, Oleksiy Venerito, Marino Milivojevic, Vladimir Torà, Núria Cano-Català, Anna Moreira, Leticia Nyssen, Olga P. Mégraud, Francis O’Morain, Colm Gisbert, Javier P. Puig, Ignasi |
author_sort | García-Morales, Natalia |
collection | PubMed |
description | Background and aims: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe. Methods: The European Registry on the management of Helicobacter pylori infection is an international, multicentre, prospective, non-interventional registry aiming to evaluate the management of Helicobacter pylori-infected patients in Europe. Countries with at least 100 cases registered from June 2013 to April 2021, and with a validated diagnostic method were analysed. Data were quality reviewed. Results: A total of 34,920 adult patients from 20 countries were included (mean age 51 years; 61% women). To establish the initial diagnosis, invasive tests were performed in 19,801 (71%) patients, non-invasive in 11,369 (41%), and both in 3437 (12%). The most frequent were histology (n = 11,885; 43%), a rapid urease test (n = 10,636; 38%) and an urea breath test (n = 7577; 27%). According to the age, invasive tests were indicated in 11,179 (77%) ≥50 years, and in 8603 (65%) <50 years. Depending on the country, the use of invasive tests ranged from 29–99% in <50 years to 60–99% in ≥50. Most of the tests used to confirm eradication were non-invasive (n = 32,540; 93%), with the urea breath test being the most frequent (n = 32,540; 78%). In 2983 (9%) post-treatment tests, histology (n = 1887; 5%) or a rapid urease test (n = 1223; 4%) were performed. Conclusion: A great heterogeneity was observed for the initial diagnosis and confirmation of the eradication. The reasons for the apparent lack of adherence to the clinical guidelines should be further explored. |
format | Online Article Text |
id | pubmed-10342434 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103424342023-07-14 Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management García-Morales, Natalia Pérez-Aísa, Ángeles Fiorini, Giulia Tepes, Bojan Castro-Fernández, Manuel Lucendo, Alfredo Voynovan, Irina Bujanda, Luis Garre, Ana Rodrigo, Luis Martínez Domínguez, Samuel Jesús Denkovski, Maja Huguet Malavés, Jose M. Jonaitis, Laimas Bumane, Renate Zaytsev, Oleg Mata Romero, Pilar Barrio, Jesús Fernández-Salazar, Luis Sarsenbaeva, Aiman Silkanovna Ortiz Polo, Inmaculada Alekseenko, Sergey Saracino, Ilaria Maria Vaira, Dino Keco-Huerga, Alma Bordin, Dmitry Gasbarrini, Antonio Lerang, Frode Rokkas, Theodore Kupčinskas, Juozas Leja, Marcis Babayeva, Gulustan Marcos Pinto, Ricardo Tonkić, Ante Smith, Sinead Phull, Perminder Buzas, Gyorgy M. Simsek, Halis Boltin, Doron Gridnyev, Oleksiy Venerito, Marino Milivojevic, Vladimir Torà, Núria Cano-Català, Anna Moreira, Leticia Nyssen, Olga P. Mégraud, Francis O’Morain, Colm Gisbert, Javier P. Puig, Ignasi J Clin Med Article Background and aims: Several methods are available to diagnose Helicobacter pylori infection. Our objective was to evaluate the tests used for both the initial diagnosis and the confirmation of eradication after treatment in Europe. Methods: The European Registry on the management of Helicobacter pylori infection is an international, multicentre, prospective, non-interventional registry aiming to evaluate the management of Helicobacter pylori-infected patients in Europe. Countries with at least 100 cases registered from June 2013 to April 2021, and with a validated diagnostic method were analysed. Data were quality reviewed. Results: A total of 34,920 adult patients from 20 countries were included (mean age 51 years; 61% women). To establish the initial diagnosis, invasive tests were performed in 19,801 (71%) patients, non-invasive in 11,369 (41%), and both in 3437 (12%). The most frequent were histology (n = 11,885; 43%), a rapid urease test (n = 10,636; 38%) and an urea breath test (n = 7577; 27%). According to the age, invasive tests were indicated in 11,179 (77%) ≥50 years, and in 8603 (65%) <50 years. Depending on the country, the use of invasive tests ranged from 29–99% in <50 years to 60–99% in ≥50. Most of the tests used to confirm eradication were non-invasive (n = 32,540; 93%), with the urea breath test being the most frequent (n = 32,540; 78%). In 2983 (9%) post-treatment tests, histology (n = 1887; 5%) or a rapid urease test (n = 1223; 4%) were performed. Conclusion: A great heterogeneity was observed for the initial diagnosis and confirmation of the eradication. The reasons for the apparent lack of adherence to the clinical guidelines should be further explored. MDPI 2023-06-28 /pmc/articles/PMC10342434/ /pubmed/37445399 http://dx.doi.org/10.3390/jcm12134363 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article García-Morales, Natalia Pérez-Aísa, Ángeles Fiorini, Giulia Tepes, Bojan Castro-Fernández, Manuel Lucendo, Alfredo Voynovan, Irina Bujanda, Luis Garre, Ana Rodrigo, Luis Martínez Domínguez, Samuel Jesús Denkovski, Maja Huguet Malavés, Jose M. Jonaitis, Laimas Bumane, Renate Zaytsev, Oleg Mata Romero, Pilar Barrio, Jesús Fernández-Salazar, Luis Sarsenbaeva, Aiman Silkanovna Ortiz Polo, Inmaculada Alekseenko, Sergey Saracino, Ilaria Maria Vaira, Dino Keco-Huerga, Alma Bordin, Dmitry Gasbarrini, Antonio Lerang, Frode Rokkas, Theodore Kupčinskas, Juozas Leja, Marcis Babayeva, Gulustan Marcos Pinto, Ricardo Tonkić, Ante Smith, Sinead Phull, Perminder Buzas, Gyorgy M. Simsek, Halis Boltin, Doron Gridnyev, Oleksiy Venerito, Marino Milivojevic, Vladimir Torà, Núria Cano-Català, Anna Moreira, Leticia Nyssen, Olga P. Mégraud, Francis O’Morain, Colm Gisbert, Javier P. Puig, Ignasi Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management |
title | Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management |
title_full | Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management |
title_fullStr | Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management |
title_full_unstemmed | Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management |
title_short | Helicobacter pylori Diagnostic Tests Used in Europe: Results of over 34,000 Patients from the European Registry on Helicobacter pylori Management |
title_sort | helicobacter pylori diagnostic tests used in europe: results of over 34,000 patients from the european registry on helicobacter pylori management |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342434/ https://www.ncbi.nlm.nih.gov/pubmed/37445399 http://dx.doi.org/10.3390/jcm12134363 |
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