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Long-Term Outcomes of Transvenous Lead Extraction: A Comparison in Patients with or without Infection from the Italian Region with the Oldest Population
Background: The gold standard for the treatment of cardiac implantable electronic devices (CIEDs)-related infection and lead malfunction is transvenous lead extraction (TLE). To date, the risk of mortality directly related to TLE procedures is relatively low, but data on post-procedural and long-ter...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342464/ https://www.ncbi.nlm.nih.gov/pubmed/37445578 http://dx.doi.org/10.3390/jcm12134543 |
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author | Barca, Luca Mascia, Giuseppe Di Donna, Paolo Sartori, Paolo Bianco, Daniele Della Bona, Roberta Benenati, Stefano Merlo, Andrea Carlo Buongiorno, Antonia Luisa Kaufman, Niki Vena, Antonio Bassetti, Matteo Porto, Italo |
author_facet | Barca, Luca Mascia, Giuseppe Di Donna, Paolo Sartori, Paolo Bianco, Daniele Della Bona, Roberta Benenati, Stefano Merlo, Andrea Carlo Buongiorno, Antonia Luisa Kaufman, Niki Vena, Antonio Bassetti, Matteo Porto, Italo |
author_sort | Barca, Luca |
collection | PubMed |
description | Background: The gold standard for the treatment of cardiac implantable electronic devices (CIEDs)-related infection and lead malfunction is transvenous lead extraction (TLE). To date, the risk of mortality directly related to TLE procedures is relatively low, but data on post-procedural and long-term mortality are limited, even more in the aging population. Methods: Consecutive patients with CIEDs who underwent TLE were retrospectively studied. The primary outcome was the endpoint of death, considering independent predictors of long-term clinical outcomes in the TLE aging population comparing patients with and without infection. Results: One hundred nineteen patients (male 77%; median age 76 years) were included in the analysis. Eighty-two patients (69%) documented infection, and thirty-seven (31%) were extracted for a different reason. Infected patients were older (80 vs. 68 years, p-value > 0.001) with more implanted catheters (p-value < 0.001). At the last follow-up (FU) available (median FU 4.1 years), mortality reached 37% of the patient population, showing a statistically significant difference between infected versus non-infected groups. At univariable analysis, age at TLE, atrial fibrillation, and anemia remained significant correlates of mortality; at multivariable analysis, only patients with anemia and atrial fibrillation have a 2.3-fold (HR 2.34; CI 1.16–4.75) and a 2.5-fold (HR 2.46; CI 1.33–4.54) increased rate of death, respectively. Conclusion: Our long-term data showed that aging patients who underwent TLE for CIED-related infection exhibit a high mortality risk during a long-term follow-up, potentially leading to a rapid and effective procedural approach in this patient population. |
format | Online Article Text |
id | pubmed-10342464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103424642023-07-14 Long-Term Outcomes of Transvenous Lead Extraction: A Comparison in Patients with or without Infection from the Italian Region with the Oldest Population Barca, Luca Mascia, Giuseppe Di Donna, Paolo Sartori, Paolo Bianco, Daniele Della Bona, Roberta Benenati, Stefano Merlo, Andrea Carlo Buongiorno, Antonia Luisa Kaufman, Niki Vena, Antonio Bassetti, Matteo Porto, Italo J Clin Med Article Background: The gold standard for the treatment of cardiac implantable electronic devices (CIEDs)-related infection and lead malfunction is transvenous lead extraction (TLE). To date, the risk of mortality directly related to TLE procedures is relatively low, but data on post-procedural and long-term mortality are limited, even more in the aging population. Methods: Consecutive patients with CIEDs who underwent TLE were retrospectively studied. The primary outcome was the endpoint of death, considering independent predictors of long-term clinical outcomes in the TLE aging population comparing patients with and without infection. Results: One hundred nineteen patients (male 77%; median age 76 years) were included in the analysis. Eighty-two patients (69%) documented infection, and thirty-seven (31%) were extracted for a different reason. Infected patients were older (80 vs. 68 years, p-value > 0.001) with more implanted catheters (p-value < 0.001). At the last follow-up (FU) available (median FU 4.1 years), mortality reached 37% of the patient population, showing a statistically significant difference between infected versus non-infected groups. At univariable analysis, age at TLE, atrial fibrillation, and anemia remained significant correlates of mortality; at multivariable analysis, only patients with anemia and atrial fibrillation have a 2.3-fold (HR 2.34; CI 1.16–4.75) and a 2.5-fold (HR 2.46; CI 1.33–4.54) increased rate of death, respectively. Conclusion: Our long-term data showed that aging patients who underwent TLE for CIED-related infection exhibit a high mortality risk during a long-term follow-up, potentially leading to a rapid and effective procedural approach in this patient population. MDPI 2023-07-07 /pmc/articles/PMC10342464/ /pubmed/37445578 http://dx.doi.org/10.3390/jcm12134543 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Barca, Luca Mascia, Giuseppe Di Donna, Paolo Sartori, Paolo Bianco, Daniele Della Bona, Roberta Benenati, Stefano Merlo, Andrea Carlo Buongiorno, Antonia Luisa Kaufman, Niki Vena, Antonio Bassetti, Matteo Porto, Italo Long-Term Outcomes of Transvenous Lead Extraction: A Comparison in Patients with or without Infection from the Italian Region with the Oldest Population |
title | Long-Term Outcomes of Transvenous Lead Extraction: A Comparison in Patients with or without Infection from the Italian Region with the Oldest Population |
title_full | Long-Term Outcomes of Transvenous Lead Extraction: A Comparison in Patients with or without Infection from the Italian Region with the Oldest Population |
title_fullStr | Long-Term Outcomes of Transvenous Lead Extraction: A Comparison in Patients with or without Infection from the Italian Region with the Oldest Population |
title_full_unstemmed | Long-Term Outcomes of Transvenous Lead Extraction: A Comparison in Patients with or without Infection from the Italian Region with the Oldest Population |
title_short | Long-Term Outcomes of Transvenous Lead Extraction: A Comparison in Patients with or without Infection from the Italian Region with the Oldest Population |
title_sort | long-term outcomes of transvenous lead extraction: a comparison in patients with or without infection from the italian region with the oldest population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342464/ https://www.ncbi.nlm.nih.gov/pubmed/37445578 http://dx.doi.org/10.3390/jcm12134543 |
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