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Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates
Nitric oxide (NO) is a key signaling molecule in almost all organisms and is active in a variety of physiological and pathological processes. Our understanding of the peculiarities and functions of this simple gas has increased considerably by extending studies to non-mammal vertebrates and inverteb...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342570/ https://www.ncbi.nlm.nih.gov/pubmed/37446358 http://dx.doi.org/10.3390/ijms241311182 |
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author | Locascio, Annamaria Annona, Giovanni Caccavale, Filomena D’Aniello, Salvatore Agnisola, Claudio Palumbo, Anna |
author_facet | Locascio, Annamaria Annona, Giovanni Caccavale, Filomena D’Aniello, Salvatore Agnisola, Claudio Palumbo, Anna |
author_sort | Locascio, Annamaria |
collection | PubMed |
description | Nitric oxide (NO) is a key signaling molecule in almost all organisms and is active in a variety of physiological and pathological processes. Our understanding of the peculiarities and functions of this simple gas has increased considerably by extending studies to non-mammal vertebrates and invertebrates. In this review, we report the nitric oxide synthase (Nos) genes so far characterized in chordates and provide an extensive, detailed, and comparative analysis of the function of NO in the aquatic chordates tunicates, cephalochordates, teleost fishes, and amphibians. This comprehensive set of data adds new elements to our understanding of Nos evolution, from the single gene commonly found in invertebrates to the three genes present in vertebrates. |
format | Online Article Text |
id | pubmed-10342570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103425702023-07-14 Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates Locascio, Annamaria Annona, Giovanni Caccavale, Filomena D’Aniello, Salvatore Agnisola, Claudio Palumbo, Anna Int J Mol Sci Review Nitric oxide (NO) is a key signaling molecule in almost all organisms and is active in a variety of physiological and pathological processes. Our understanding of the peculiarities and functions of this simple gas has increased considerably by extending studies to non-mammal vertebrates and invertebrates. In this review, we report the nitric oxide synthase (Nos) genes so far characterized in chordates and provide an extensive, detailed, and comparative analysis of the function of NO in the aquatic chordates tunicates, cephalochordates, teleost fishes, and amphibians. This comprehensive set of data adds new elements to our understanding of Nos evolution, from the single gene commonly found in invertebrates to the three genes present in vertebrates. MDPI 2023-07-06 /pmc/articles/PMC10342570/ /pubmed/37446358 http://dx.doi.org/10.3390/ijms241311182 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Locascio, Annamaria Annona, Giovanni Caccavale, Filomena D’Aniello, Salvatore Agnisola, Claudio Palumbo, Anna Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates |
title | Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates |
title_full | Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates |
title_fullStr | Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates |
title_full_unstemmed | Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates |
title_short | Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates |
title_sort | nitric oxide function and nitric oxide synthase evolution in aquatic chordates |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342570/ https://www.ncbi.nlm.nih.gov/pubmed/37446358 http://dx.doi.org/10.3390/ijms241311182 |
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