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Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates

Nitric oxide (NO) is a key signaling molecule in almost all organisms and is active in a variety of physiological and pathological processes. Our understanding of the peculiarities and functions of this simple gas has increased considerably by extending studies to non-mammal vertebrates and inverteb...

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Autores principales: Locascio, Annamaria, Annona, Giovanni, Caccavale, Filomena, D’Aniello, Salvatore, Agnisola, Claudio, Palumbo, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342570/
https://www.ncbi.nlm.nih.gov/pubmed/37446358
http://dx.doi.org/10.3390/ijms241311182
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author Locascio, Annamaria
Annona, Giovanni
Caccavale, Filomena
D’Aniello, Salvatore
Agnisola, Claudio
Palumbo, Anna
author_facet Locascio, Annamaria
Annona, Giovanni
Caccavale, Filomena
D’Aniello, Salvatore
Agnisola, Claudio
Palumbo, Anna
author_sort Locascio, Annamaria
collection PubMed
description Nitric oxide (NO) is a key signaling molecule in almost all organisms and is active in a variety of physiological and pathological processes. Our understanding of the peculiarities and functions of this simple gas has increased considerably by extending studies to non-mammal vertebrates and invertebrates. In this review, we report the nitric oxide synthase (Nos) genes so far characterized in chordates and provide an extensive, detailed, and comparative analysis of the function of NO in the aquatic chordates tunicates, cephalochordates, teleost fishes, and amphibians. This comprehensive set of data adds new elements to our understanding of Nos evolution, from the single gene commonly found in invertebrates to the three genes present in vertebrates.
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spelling pubmed-103425702023-07-14 Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates Locascio, Annamaria Annona, Giovanni Caccavale, Filomena D’Aniello, Salvatore Agnisola, Claudio Palumbo, Anna Int J Mol Sci Review Nitric oxide (NO) is a key signaling molecule in almost all organisms and is active in a variety of physiological and pathological processes. Our understanding of the peculiarities and functions of this simple gas has increased considerably by extending studies to non-mammal vertebrates and invertebrates. In this review, we report the nitric oxide synthase (Nos) genes so far characterized in chordates and provide an extensive, detailed, and comparative analysis of the function of NO in the aquatic chordates tunicates, cephalochordates, teleost fishes, and amphibians. This comprehensive set of data adds new elements to our understanding of Nos evolution, from the single gene commonly found in invertebrates to the three genes present in vertebrates. MDPI 2023-07-06 /pmc/articles/PMC10342570/ /pubmed/37446358 http://dx.doi.org/10.3390/ijms241311182 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Locascio, Annamaria
Annona, Giovanni
Caccavale, Filomena
D’Aniello, Salvatore
Agnisola, Claudio
Palumbo, Anna
Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates
title Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates
title_full Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates
title_fullStr Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates
title_full_unstemmed Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates
title_short Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates
title_sort nitric oxide function and nitric oxide synthase evolution in aquatic chordates
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342570/
https://www.ncbi.nlm.nih.gov/pubmed/37446358
http://dx.doi.org/10.3390/ijms241311182
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