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Tranexamic Acid Use in Pediatric Craniotomies at a Large Tertiary Care Pediatric Hospital: A Five Year Retrospective Study

Tranexamic acid (TXA), a synthetic antifibrinolytic drug, has proven efficacy and is recommended for major pediatric surgery to decrease perioperative blood loss. Accumulating evidence suggests that TXA reduces bleeding and transfusion in a variety of adult neurosurgical settings. However, there is...

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Autores principales: Wang, Jue T., Seshadri, Samir C., Butler, Carolyn G., Staffa, Steven J., Kordun, Anna S., Lukovits, Karina E., Goobie, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342645/
https://www.ncbi.nlm.nih.gov/pubmed/37445437
http://dx.doi.org/10.3390/jcm12134403
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author Wang, Jue T.
Seshadri, Samir C.
Butler, Carolyn G.
Staffa, Steven J.
Kordun, Anna S.
Lukovits, Karina E.
Goobie, Susan M.
author_facet Wang, Jue T.
Seshadri, Samir C.
Butler, Carolyn G.
Staffa, Steven J.
Kordun, Anna S.
Lukovits, Karina E.
Goobie, Susan M.
author_sort Wang, Jue T.
collection PubMed
description Tranexamic acid (TXA), a synthetic antifibrinolytic drug, has proven efficacy and is recommended for major pediatric surgery to decrease perioperative blood loss. Accumulating evidence suggests that TXA reduces bleeding and transfusion in a variety of adult neurosurgical settings. However, there is a paucity of research regarding TXA indications for pediatric neurosurgery and thus, there are currently no recommendations for its use with this specific population. The objective of this study is to evaluate the existing practice of TXA administration for pediatric neurosurgery at a U.S. tertiary care pediatric hospital over a five-year period. The authors conclude that TXA administration is feasible and should be considered for pediatric neurosurgical cases where potential blood loss is a concern.
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spelling pubmed-103426452023-07-14 Tranexamic Acid Use in Pediatric Craniotomies at a Large Tertiary Care Pediatric Hospital: A Five Year Retrospective Study Wang, Jue T. Seshadri, Samir C. Butler, Carolyn G. Staffa, Steven J. Kordun, Anna S. Lukovits, Karina E. Goobie, Susan M. J Clin Med Article Tranexamic acid (TXA), a synthetic antifibrinolytic drug, has proven efficacy and is recommended for major pediatric surgery to decrease perioperative blood loss. Accumulating evidence suggests that TXA reduces bleeding and transfusion in a variety of adult neurosurgical settings. However, there is a paucity of research regarding TXA indications for pediatric neurosurgery and thus, there are currently no recommendations for its use with this specific population. The objective of this study is to evaluate the existing practice of TXA administration for pediatric neurosurgery at a U.S. tertiary care pediatric hospital over a five-year period. The authors conclude that TXA administration is feasible and should be considered for pediatric neurosurgical cases where potential blood loss is a concern. MDPI 2023-06-30 /pmc/articles/PMC10342645/ /pubmed/37445437 http://dx.doi.org/10.3390/jcm12134403 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Jue T.
Seshadri, Samir C.
Butler, Carolyn G.
Staffa, Steven J.
Kordun, Anna S.
Lukovits, Karina E.
Goobie, Susan M.
Tranexamic Acid Use in Pediatric Craniotomies at a Large Tertiary Care Pediatric Hospital: A Five Year Retrospective Study
title Tranexamic Acid Use in Pediatric Craniotomies at a Large Tertiary Care Pediatric Hospital: A Five Year Retrospective Study
title_full Tranexamic Acid Use in Pediatric Craniotomies at a Large Tertiary Care Pediatric Hospital: A Five Year Retrospective Study
title_fullStr Tranexamic Acid Use in Pediatric Craniotomies at a Large Tertiary Care Pediatric Hospital: A Five Year Retrospective Study
title_full_unstemmed Tranexamic Acid Use in Pediatric Craniotomies at a Large Tertiary Care Pediatric Hospital: A Five Year Retrospective Study
title_short Tranexamic Acid Use in Pediatric Craniotomies at a Large Tertiary Care Pediatric Hospital: A Five Year Retrospective Study
title_sort tranexamic acid use in pediatric craniotomies at a large tertiary care pediatric hospital: a five year retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342645/
https://www.ncbi.nlm.nih.gov/pubmed/37445437
http://dx.doi.org/10.3390/jcm12134403
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