Involvement of the p38/MK2 Pathway in MCLR Hepatotoxicity Revealed through MAPK Pharmacological Inhibition and Phosphoproteomics in HepaRG Cells

Microcystin-leucine arginine (MCLR) is one of the most common and toxic microcystin variants, a class of cyanotoxins produced by cyanobacteria. A major molecular mechanism for MCLR-elicited liver toxicity involves the dysregulation of protein phosphorylation through protein phosphatase (PP) inhibiti...

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Detalles Bibliográficos
Autores principales: Lynch, Katherine D., Iverson, Dayne T., Bachhav, Namrata K., Call, Michael Ridge, Yue, Guihua Eileen, Prasad, Bhagwat, Clarke, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342686/
https://www.ncbi.nlm.nih.gov/pubmed/37446360
http://dx.doi.org/10.3390/ijms241311168

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