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Precision Delivery of Steroids as a Rescue Therapy for Gastrointestinal Graft-versus-Host Disease in Pediatric Stem Cell Transplant Recipients
Graft versus host disease (GVHD) is one of the most serious complications following stem cell transplant in children and is a major cause of morbidity and mortality. Corticosteroids remain the mainstay of treatment, and although a majority of children respond to systemic steroids, those refractory t...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342730/ https://www.ncbi.nlm.nih.gov/pubmed/37445274 http://dx.doi.org/10.3390/jcm12134229 |
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author | Levitte, Steven Ganguly, Abantika Frolik, Sophie Guevara-Tique, Alix A. Patel, Shaini Tadas, Ann Klein, Orly Shyr, David Agarwal-Hashmi, Rajni Beach, Lynn Callard, Elizabeth Weinacht, Katja Bertaina, Alice Thakor, Avnesh S. |
author_facet | Levitte, Steven Ganguly, Abantika Frolik, Sophie Guevara-Tique, Alix A. Patel, Shaini Tadas, Ann Klein, Orly Shyr, David Agarwal-Hashmi, Rajni Beach, Lynn Callard, Elizabeth Weinacht, Katja Bertaina, Alice Thakor, Avnesh S. |
author_sort | Levitte, Steven |
collection | PubMed |
description | Graft versus host disease (GVHD) is one of the most serious complications following stem cell transplant in children and is a major cause of morbidity and mortality. Corticosteroids remain the mainstay of treatment, and although a majority of children respond to systemic steroids, those refractory to or dependent upon corticosteroids suffer from complications secondary to long-term steroid administration. This problem has prompted consideration of steroid-sparing treatment strategies, although the time to clinical remission can be variable. Intraarterial corticosteroid delivery has been used in adults as a rescue therapy in steroid-resistant patients, but its use in children has been limited. We investigated the feasibility of intraarterial steroid administration into the bowel and/or liver in a cohort of six pediatric patients with acute GVHD. All patients successfully underwent treatment with no serious adverse effects. Five of five (100%) patients with gastrointestinal bleeding due to GVHD had rapid symptom improvement by 48 h, which was durable up to three weeks. Three of four (75%) patients with hepatic GVHD had improved cholestasis following intraarterial steroid administration. Our experience with this small cohort preliminarily demonstrated the feasibility and safety of intraarterial steroid administration in children with acute GVHD. This approach warrants consideration as a rescue therapy in steroid-refractory cases and as a “bridge” therapy for children with severe acute GVHD who are transitioning to steroid-sparing regimens. |
format | Online Article Text |
id | pubmed-10342730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103427302023-07-14 Precision Delivery of Steroids as a Rescue Therapy for Gastrointestinal Graft-versus-Host Disease in Pediatric Stem Cell Transplant Recipients Levitte, Steven Ganguly, Abantika Frolik, Sophie Guevara-Tique, Alix A. Patel, Shaini Tadas, Ann Klein, Orly Shyr, David Agarwal-Hashmi, Rajni Beach, Lynn Callard, Elizabeth Weinacht, Katja Bertaina, Alice Thakor, Avnesh S. J Clin Med Brief Report Graft versus host disease (GVHD) is one of the most serious complications following stem cell transplant in children and is a major cause of morbidity and mortality. Corticosteroids remain the mainstay of treatment, and although a majority of children respond to systemic steroids, those refractory to or dependent upon corticosteroids suffer from complications secondary to long-term steroid administration. This problem has prompted consideration of steroid-sparing treatment strategies, although the time to clinical remission can be variable. Intraarterial corticosteroid delivery has been used in adults as a rescue therapy in steroid-resistant patients, but its use in children has been limited. We investigated the feasibility of intraarterial steroid administration into the bowel and/or liver in a cohort of six pediatric patients with acute GVHD. All patients successfully underwent treatment with no serious adverse effects. Five of five (100%) patients with gastrointestinal bleeding due to GVHD had rapid symptom improvement by 48 h, which was durable up to three weeks. Three of four (75%) patients with hepatic GVHD had improved cholestasis following intraarterial steroid administration. Our experience with this small cohort preliminarily demonstrated the feasibility and safety of intraarterial steroid administration in children with acute GVHD. This approach warrants consideration as a rescue therapy in steroid-refractory cases and as a “bridge” therapy for children with severe acute GVHD who are transitioning to steroid-sparing regimens. MDPI 2023-06-23 /pmc/articles/PMC10342730/ /pubmed/37445274 http://dx.doi.org/10.3390/jcm12134229 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Levitte, Steven Ganguly, Abantika Frolik, Sophie Guevara-Tique, Alix A. Patel, Shaini Tadas, Ann Klein, Orly Shyr, David Agarwal-Hashmi, Rajni Beach, Lynn Callard, Elizabeth Weinacht, Katja Bertaina, Alice Thakor, Avnesh S. Precision Delivery of Steroids as a Rescue Therapy for Gastrointestinal Graft-versus-Host Disease in Pediatric Stem Cell Transplant Recipients |
title | Precision Delivery of Steroids as a Rescue Therapy for Gastrointestinal Graft-versus-Host Disease in Pediatric Stem Cell Transplant Recipients |
title_full | Precision Delivery of Steroids as a Rescue Therapy for Gastrointestinal Graft-versus-Host Disease in Pediatric Stem Cell Transplant Recipients |
title_fullStr | Precision Delivery of Steroids as a Rescue Therapy for Gastrointestinal Graft-versus-Host Disease in Pediatric Stem Cell Transplant Recipients |
title_full_unstemmed | Precision Delivery of Steroids as a Rescue Therapy for Gastrointestinal Graft-versus-Host Disease in Pediatric Stem Cell Transplant Recipients |
title_short | Precision Delivery of Steroids as a Rescue Therapy for Gastrointestinal Graft-versus-Host Disease in Pediatric Stem Cell Transplant Recipients |
title_sort | precision delivery of steroids as a rescue therapy for gastrointestinal graft-versus-host disease in pediatric stem cell transplant recipients |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342730/ https://www.ncbi.nlm.nih.gov/pubmed/37445274 http://dx.doi.org/10.3390/jcm12134229 |
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