Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates

Although the overall prognosis of differentiated thyroid cancer (DTC), the most common endocrine malignancy, is favorable, a subset of patients exhibits aggressive features. Therefore, preclinical models that can be utilized to investigate DTC pathogenesis and novel treatments are necessary. Various...

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Detalles Bibliográficos
Autores principales: Choi, Hye Ryeon, Kim, Kwangsoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342769/
https://www.ncbi.nlm.nih.gov/pubmed/37446316
http://dx.doi.org/10.3390/ijms241311138
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author Choi, Hye Ryeon
Kim, Kwangsoon
author_facet Choi, Hye Ryeon
Kim, Kwangsoon
author_sort Choi, Hye Ryeon
collection PubMed
description Although the overall prognosis of differentiated thyroid cancer (DTC), the most common endocrine malignancy, is favorable, a subset of patients exhibits aggressive features. Therefore, preclinical models that can be utilized to investigate DTC pathogenesis and novel treatments are necessary. Various mouse models have been developed based on advances in thyroid cancer genetics. This review focuses on recent progress in mouse models that have been developed to elucidate the molecular pathogenesis of DTC.
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spelling pubmed-103427692023-07-14 Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates Choi, Hye Ryeon Kim, Kwangsoon Int J Mol Sci Review Although the overall prognosis of differentiated thyroid cancer (DTC), the most common endocrine malignancy, is favorable, a subset of patients exhibits aggressive features. Therefore, preclinical models that can be utilized to investigate DTC pathogenesis and novel treatments are necessary. Various mouse models have been developed based on advances in thyroid cancer genetics. This review focuses on recent progress in mouse models that have been developed to elucidate the molecular pathogenesis of DTC. MDPI 2023-07-06 /pmc/articles/PMC10342769/ /pubmed/37446316 http://dx.doi.org/10.3390/ijms241311138 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Choi, Hye Ryeon
Kim, Kwangsoon
Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates
title Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates
title_full Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates
title_fullStr Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates
title_full_unstemmed Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates
title_short Mouse Models to Examine Differentiated Thyroid Cancer Pathogenesis: Recent Updates
title_sort mouse models to examine differentiated thyroid cancer pathogenesis: recent updates
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342769/
https://www.ncbi.nlm.nih.gov/pubmed/37446316
http://dx.doi.org/10.3390/ijms241311138
work_keys_str_mv AT choihyeryeon mousemodelstoexaminedifferentiatedthyroidcancerpathogenesisrecentupdates
AT kimkwangsoon mousemodelstoexaminedifferentiatedthyroidcancerpathogenesisrecentupdates

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