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Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US

This study describes the characteristics of women who contacted an active program performing uterus transplantation (UTx) in the US, expressing interest in becoming a uterus transplant recipient or a living donor. Basic demographic and self-reported clinical information was collected from women who...

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Autores principales: Johannesson, Liza, Testa, Giuliano, Beshara, Menas M., da Graca, Briget, Walter, Jessica R., Quintini, Cristiano, Latif, Nawar, Hashimoto, Koji, Richards, Elliott G., O’Neill, Kathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342774/
https://www.ncbi.nlm.nih.gov/pubmed/37445236
http://dx.doi.org/10.3390/jcm12134201
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author Johannesson, Liza
Testa, Giuliano
Beshara, Menas M.
da Graca, Briget
Walter, Jessica R.
Quintini, Cristiano
Latif, Nawar
Hashimoto, Koji
Richards, Elliott G.
O’Neill, Kathleen
author_facet Johannesson, Liza
Testa, Giuliano
Beshara, Menas M.
da Graca, Briget
Walter, Jessica R.
Quintini, Cristiano
Latif, Nawar
Hashimoto, Koji
Richards, Elliott G.
O’Neill, Kathleen
author_sort Johannesson, Liza
collection PubMed
description This study describes the characteristics of women who contacted an active program performing uterus transplantation (UTx) in the US, expressing interest in becoming a uterus transplant recipient or a living donor. Basic demographic and self-reported clinical information was collected from women who contacted any of the three US UTx programs from 2015 to July 2022. The three centers received 5194 inquiries about becoming a UTx recipient during the study timeframe. Among those reporting a cause of infertility, almost all of the reports (4066/4331, 94%) were absence of a uterus, either congenitally (794/4066, 20%) or secondary to hysterectomy (3272/4066, 80%). The mean age was 34 years, and 49% (2545/5194) had at least one child at the time of application. The two centers using living donors received 2217 inquiries about becoming living donors. The mean age was 34 years, and 60% (1330/2217) had given birth to ≥1 child. While most of the UTx clinical trial evidence has focused on young women with congenital absence of the uterus, these results show interest from a much broader patient population in terms of age, cause of infertility, and parity. These results raise questions about whether and to what extent the indications and eligibility criteria for UTx should be expanded as the procedure transitions from the experimental phase to being offered as a clinical treatment.
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spelling pubmed-103427742023-07-14 Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US Johannesson, Liza Testa, Giuliano Beshara, Menas M. da Graca, Briget Walter, Jessica R. Quintini, Cristiano Latif, Nawar Hashimoto, Koji Richards, Elliott G. O’Neill, Kathleen J Clin Med Article This study describes the characteristics of women who contacted an active program performing uterus transplantation (UTx) in the US, expressing interest in becoming a uterus transplant recipient or a living donor. Basic demographic and self-reported clinical information was collected from women who contacted any of the three US UTx programs from 2015 to July 2022. The three centers received 5194 inquiries about becoming a UTx recipient during the study timeframe. Among those reporting a cause of infertility, almost all of the reports (4066/4331, 94%) were absence of a uterus, either congenitally (794/4066, 20%) or secondary to hysterectomy (3272/4066, 80%). The mean age was 34 years, and 49% (2545/5194) had at least one child at the time of application. The two centers using living donors received 2217 inquiries about becoming living donors. The mean age was 34 years, and 60% (1330/2217) had given birth to ≥1 child. While most of the UTx clinical trial evidence has focused on young women with congenital absence of the uterus, these results show interest from a much broader patient population in terms of age, cause of infertility, and parity. These results raise questions about whether and to what extent the indications and eligibility criteria for UTx should be expanded as the procedure transitions from the experimental phase to being offered as a clinical treatment. MDPI 2023-06-21 /pmc/articles/PMC10342774/ /pubmed/37445236 http://dx.doi.org/10.3390/jcm12134201 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Johannesson, Liza
Testa, Giuliano
Beshara, Menas M.
da Graca, Briget
Walter, Jessica R.
Quintini, Cristiano
Latif, Nawar
Hashimoto, Koji
Richards, Elliott G.
O’Neill, Kathleen
Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US
title Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US
title_full Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US
title_fullStr Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US
title_full_unstemmed Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US
title_short Awareness and Interest in Uterus Transplantation over Time: Analysis of Those Seeking Surgical Correction for Uterine-Factor Infertility in the US
title_sort awareness and interest in uterus transplantation over time: analysis of those seeking surgical correction for uterine-factor infertility in the us
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342774/
https://www.ncbi.nlm.nih.gov/pubmed/37445236
http://dx.doi.org/10.3390/jcm12134201
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