Cargando…
Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors
This study aims to summarize the modifiable risk factors for pancreatic ductal adenocarcinoma (PDAC) that have been known for a long time, as well as information from the most recent reports. As a cancer with a late diagnosis and poor prognosis, accurate analysis of PDAC risk factors is warranted. T...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342815/ https://www.ncbi.nlm.nih.gov/pubmed/37445352 http://dx.doi.org/10.3390/jcm12134318 |
_version_ | 1785072589656293376 |
---|---|
author | Michalak, Natalia Małecka-Wojciesko, Ewa |
author_facet | Michalak, Natalia Małecka-Wojciesko, Ewa |
author_sort | Michalak, Natalia |
collection | PubMed |
description | This study aims to summarize the modifiable risk factors for pancreatic ductal adenocarcinoma (PDAC) that have been known for a long time, as well as information from the most recent reports. As a cancer with a late diagnosis and poor prognosis, accurate analysis of PDAC risk factors is warranted. The incidence of this cancer continues to rise, and the five-year survival rate is the lowest with respect to other tumors. The influence of cigarette smoking, alcohol consumption, and chronic pancreatitis in increasing the risk of pancreatic ductal adenocarcinoma is continually being confirmed. There are also newly emerging reports relating to the impact of lifestyle, including physical activity, the gut and oral microbiome, and hepatotropic viruses. A precise understanding of PDAC risk factors can help to identify groups of high-risk patients, and this may contribute to population awareness and education as well as earlier diagnoses with possible better treatment outcomes. |
format | Online Article Text |
id | pubmed-10342815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103428152023-07-14 Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors Michalak, Natalia Małecka-Wojciesko, Ewa J Clin Med Review This study aims to summarize the modifiable risk factors for pancreatic ductal adenocarcinoma (PDAC) that have been known for a long time, as well as information from the most recent reports. As a cancer with a late diagnosis and poor prognosis, accurate analysis of PDAC risk factors is warranted. The incidence of this cancer continues to rise, and the five-year survival rate is the lowest with respect to other tumors. The influence of cigarette smoking, alcohol consumption, and chronic pancreatitis in increasing the risk of pancreatic ductal adenocarcinoma is continually being confirmed. There are also newly emerging reports relating to the impact of lifestyle, including physical activity, the gut and oral microbiome, and hepatotropic viruses. A precise understanding of PDAC risk factors can help to identify groups of high-risk patients, and this may contribute to population awareness and education as well as earlier diagnoses with possible better treatment outcomes. MDPI 2023-06-27 /pmc/articles/PMC10342815/ /pubmed/37445352 http://dx.doi.org/10.3390/jcm12134318 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Michalak, Natalia Małecka-Wojciesko, Ewa Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors |
title | Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors |
title_full | Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors |
title_fullStr | Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors |
title_full_unstemmed | Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors |
title_short | Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors |
title_sort | modifiable pancreatic ductal adenocarcinoma (pdac) risk factors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342815/ https://www.ncbi.nlm.nih.gov/pubmed/37445352 http://dx.doi.org/10.3390/jcm12134318 |
work_keys_str_mv | AT michalaknatalia modifiablepancreaticductaladenocarcinomapdacriskfactors AT małeckawojcieskoewa modifiablepancreaticductaladenocarcinomapdacriskfactors |