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Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors

This study aims to summarize the modifiable risk factors for pancreatic ductal adenocarcinoma (PDAC) that have been known for a long time, as well as information from the most recent reports. As a cancer with a late diagnosis and poor prognosis, accurate analysis of PDAC risk factors is warranted. T...

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Detalles Bibliográficos
Autores principales: Michalak, Natalia, Małecka-Wojciesko, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342815/
https://www.ncbi.nlm.nih.gov/pubmed/37445352
http://dx.doi.org/10.3390/jcm12134318
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author Michalak, Natalia
Małecka-Wojciesko, Ewa
author_facet Michalak, Natalia
Małecka-Wojciesko, Ewa
author_sort Michalak, Natalia
collection PubMed
description This study aims to summarize the modifiable risk factors for pancreatic ductal adenocarcinoma (PDAC) that have been known for a long time, as well as information from the most recent reports. As a cancer with a late diagnosis and poor prognosis, accurate analysis of PDAC risk factors is warranted. The incidence of this cancer continues to rise, and the five-year survival rate is the lowest with respect to other tumors. The influence of cigarette smoking, alcohol consumption, and chronic pancreatitis in increasing the risk of pancreatic ductal adenocarcinoma is continually being confirmed. There are also newly emerging reports relating to the impact of lifestyle, including physical activity, the gut and oral microbiome, and hepatotropic viruses. A precise understanding of PDAC risk factors can help to identify groups of high-risk patients, and this may contribute to population awareness and education as well as earlier diagnoses with possible better treatment outcomes.
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spelling pubmed-103428152023-07-14 Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors Michalak, Natalia Małecka-Wojciesko, Ewa J Clin Med Review This study aims to summarize the modifiable risk factors for pancreatic ductal adenocarcinoma (PDAC) that have been known for a long time, as well as information from the most recent reports. As a cancer with a late diagnosis and poor prognosis, accurate analysis of PDAC risk factors is warranted. The incidence of this cancer continues to rise, and the five-year survival rate is the lowest with respect to other tumors. The influence of cigarette smoking, alcohol consumption, and chronic pancreatitis in increasing the risk of pancreatic ductal adenocarcinoma is continually being confirmed. There are also newly emerging reports relating to the impact of lifestyle, including physical activity, the gut and oral microbiome, and hepatotropic viruses. A precise understanding of PDAC risk factors can help to identify groups of high-risk patients, and this may contribute to population awareness and education as well as earlier diagnoses with possible better treatment outcomes. MDPI 2023-06-27 /pmc/articles/PMC10342815/ /pubmed/37445352 http://dx.doi.org/10.3390/jcm12134318 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Michalak, Natalia
Małecka-Wojciesko, Ewa
Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors
title Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors
title_full Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors
title_fullStr Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors
title_full_unstemmed Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors
title_short Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors
title_sort modifiable pancreatic ductal adenocarcinoma (pdac) risk factors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342815/
https://www.ncbi.nlm.nih.gov/pubmed/37445352
http://dx.doi.org/10.3390/jcm12134318
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