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Three-Dimensional Characterization of Aortic Root Motion by Vascular Deformation Mapping

The aorta is in constant motion due to the combination of cyclic loading and unloading with its mechanical coupling to the contractile left ventricle (LV) myocardium. This aortic root motion has been proposed as a marker for aortic disease progression. Aortic root motion extraction techniques have b...

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Autores principales: Kim, Taeouk, Tjahjadi, Nic S., He, Xuehuan, van Herwaarden, JA, Patel, Himanshu J., Burris, Nicholas S., Figueroa, C. Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342953/
https://www.ncbi.nlm.nih.gov/pubmed/37445507
http://dx.doi.org/10.3390/jcm12134471
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author Kim, Taeouk
Tjahjadi, Nic S.
He, Xuehuan
van Herwaarden, JA
Patel, Himanshu J.
Burris, Nicholas S.
Figueroa, C. Alberto
author_facet Kim, Taeouk
Tjahjadi, Nic S.
He, Xuehuan
van Herwaarden, JA
Patel, Himanshu J.
Burris, Nicholas S.
Figueroa, C. Alberto
author_sort Kim, Taeouk
collection PubMed
description The aorta is in constant motion due to the combination of cyclic loading and unloading with its mechanical coupling to the contractile left ventricle (LV) myocardium. This aortic root motion has been proposed as a marker for aortic disease progression. Aortic root motion extraction techniques have been mostly based on 2D image analysis and have thus lacked a rigorous description of the different components of aortic root motion (e.g., axial versus in-plane). In this study, we utilized a novel technique termed vascular deformation mapping (VDM(D)) to extract 3D aortic root motion from dynamic computed tomography angiography images. Aortic root displacement (axial and in-plane), area ratio and distensibility, axial tilt, aortic rotation, and LV/Ao angles were extracted and compared for four different subject groups: non-aneurysmal, TAA, Marfan, and repair. The repair group showed smaller aortic root displacement, aortic rotation, and distensibility than the other groups. The repair group was also the only group that showed a larger relative in-plane displacement than relative axial displacement. The Marfan group showed the largest heterogeneity in aortic root displacement, distensibility, and age. The non-aneurysmal group showed a negative correlation between age and distensibility, consistent with previous studies. Our results revealed a strong positive correlation between LV/Ao angle and relative axial displacement and a strong negative correlation between LV/Ao angle and relative in-plane displacement. VDM(D)-derived 3D aortic root motion can be used in future studies to define improved boundary conditions for aortic wall stress analysis.
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spelling pubmed-103429532023-07-14 Three-Dimensional Characterization of Aortic Root Motion by Vascular Deformation Mapping Kim, Taeouk Tjahjadi, Nic S. He, Xuehuan van Herwaarden, JA Patel, Himanshu J. Burris, Nicholas S. Figueroa, C. Alberto J Clin Med Article The aorta is in constant motion due to the combination of cyclic loading and unloading with its mechanical coupling to the contractile left ventricle (LV) myocardium. This aortic root motion has been proposed as a marker for aortic disease progression. Aortic root motion extraction techniques have been mostly based on 2D image analysis and have thus lacked a rigorous description of the different components of aortic root motion (e.g., axial versus in-plane). In this study, we utilized a novel technique termed vascular deformation mapping (VDM(D)) to extract 3D aortic root motion from dynamic computed tomography angiography images. Aortic root displacement (axial and in-plane), area ratio and distensibility, axial tilt, aortic rotation, and LV/Ao angles were extracted and compared for four different subject groups: non-aneurysmal, TAA, Marfan, and repair. The repair group showed smaller aortic root displacement, aortic rotation, and distensibility than the other groups. The repair group was also the only group that showed a larger relative in-plane displacement than relative axial displacement. The Marfan group showed the largest heterogeneity in aortic root displacement, distensibility, and age. The non-aneurysmal group showed a negative correlation between age and distensibility, consistent with previous studies. Our results revealed a strong positive correlation between LV/Ao angle and relative axial displacement and a strong negative correlation between LV/Ao angle and relative in-plane displacement. VDM(D)-derived 3D aortic root motion can be used in future studies to define improved boundary conditions for aortic wall stress analysis. MDPI 2023-07-04 /pmc/articles/PMC10342953/ /pubmed/37445507 http://dx.doi.org/10.3390/jcm12134471 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Taeouk
Tjahjadi, Nic S.
He, Xuehuan
van Herwaarden, JA
Patel, Himanshu J.
Burris, Nicholas S.
Figueroa, C. Alberto
Three-Dimensional Characterization of Aortic Root Motion by Vascular Deformation Mapping
title Three-Dimensional Characterization of Aortic Root Motion by Vascular Deformation Mapping
title_full Three-Dimensional Characterization of Aortic Root Motion by Vascular Deformation Mapping
title_fullStr Three-Dimensional Characterization of Aortic Root Motion by Vascular Deformation Mapping
title_full_unstemmed Three-Dimensional Characterization of Aortic Root Motion by Vascular Deformation Mapping
title_short Three-Dimensional Characterization of Aortic Root Motion by Vascular Deformation Mapping
title_sort three-dimensional characterization of aortic root motion by vascular deformation mapping
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342953/
https://www.ncbi.nlm.nih.gov/pubmed/37445507
http://dx.doi.org/10.3390/jcm12134471
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