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Association between Body Composition Contents and Hepatic Fibrosis in Sarcopenic Obesity
It is well established that sarcopenic obesity (SO) is linked to many diseases such as metabolic and non-alcoholic fatty liver diseases, but there is little known about the relationship between SO and hepatic fibrosis progression in chronic liver disease. This study compared body composition content...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342967/ https://www.ncbi.nlm.nih.gov/pubmed/37445314 http://dx.doi.org/10.3390/jcm12134279 |
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author | Kim, Tae-Hoon Jeong, Chang-Won Lee, ChungSub Noh, SiHyeong Lim, Dong Wook Kim, Jin Woong Kim, Hyung Joong Kim, Youe Ree |
author_facet | Kim, Tae-Hoon Jeong, Chang-Won Lee, ChungSub Noh, SiHyeong Lim, Dong Wook Kim, Jin Woong Kim, Hyung Joong Kim, Youe Ree |
author_sort | Kim, Tae-Hoon |
collection | PubMed |
description | It is well established that sarcopenic obesity (SO) is linked to many diseases such as metabolic and non-alcoholic fatty liver diseases, but there is little known about the relationship between SO and hepatic fibrosis progression in chronic liver disease. This study compared body composition contents in patients with non-obesity (NOb) and SO using abdominal magnetic resonance imaging and investigated the relationship between hepatic fibrosis and SO factors. This retrospective study enrolled 60 patients (28 NOb; 32 SO) from June 2014 to December 2020. Patients underwent histopathologic investigation where they classified fibrosis stages based on the Meta-analysis of Histological Data in Viral Hepatitis fibrosis scoring system. Muscle and fat areas at the third lumber vertebra level were assessed. The variation in the areas of muscle (MA), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) among fibrosis stages, and associations between hepatic fibrosis and SO factors, were analyzed. There were significant differences in SAT and VAT (p < 0.001), whereas there was no difference in MA (p = 0.064). There were significant differences in MA/SAT (p = 0.009), MA/VAT (p < 0.001), and MA/(SAT+VAT) (p < 0.001). In all the patients, hepatic fibrosis positively correlated with serum aspartate aminotransferase level (AST, R = 0.324; p = 0.025). Especially in SO patients, hepatic fibrosis closely correlated with body mass index (BMI, R = 0.443; p = 0.011), AST (R = 0.415; p = 0.044), VAT (R = 0.653; p < 0.001), MA/VAT (R = −0.605; p < 0.001), and MA/(SAT+VAT) (R = −0.416; p = 0.018). However, there was no association in NOb patients. This study demonstrated that SO patients had larger SAT and VAT than NOb patients. Hepatic fibrosis in SO positively correlated with body visceral fat composition in combination with BMI and AST level. These findings will be useful for understanding the relationship between the hepatic manifestation of fibrosis and body fat composition in sarcopenia and SO. |
format | Online Article Text |
id | pubmed-10342967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103429672023-07-14 Association between Body Composition Contents and Hepatic Fibrosis in Sarcopenic Obesity Kim, Tae-Hoon Jeong, Chang-Won Lee, ChungSub Noh, SiHyeong Lim, Dong Wook Kim, Jin Woong Kim, Hyung Joong Kim, Youe Ree J Clin Med Article It is well established that sarcopenic obesity (SO) is linked to many diseases such as metabolic and non-alcoholic fatty liver diseases, but there is little known about the relationship between SO and hepatic fibrosis progression in chronic liver disease. This study compared body composition contents in patients with non-obesity (NOb) and SO using abdominal magnetic resonance imaging and investigated the relationship between hepatic fibrosis and SO factors. This retrospective study enrolled 60 patients (28 NOb; 32 SO) from June 2014 to December 2020. Patients underwent histopathologic investigation where they classified fibrosis stages based on the Meta-analysis of Histological Data in Viral Hepatitis fibrosis scoring system. Muscle and fat areas at the third lumber vertebra level were assessed. The variation in the areas of muscle (MA), subcutaneous adipose tissue (SAT), and visceral adipose tissue (VAT) among fibrosis stages, and associations between hepatic fibrosis and SO factors, were analyzed. There were significant differences in SAT and VAT (p < 0.001), whereas there was no difference in MA (p = 0.064). There were significant differences in MA/SAT (p = 0.009), MA/VAT (p < 0.001), and MA/(SAT+VAT) (p < 0.001). In all the patients, hepatic fibrosis positively correlated with serum aspartate aminotransferase level (AST, R = 0.324; p = 0.025). Especially in SO patients, hepatic fibrosis closely correlated with body mass index (BMI, R = 0.443; p = 0.011), AST (R = 0.415; p = 0.044), VAT (R = 0.653; p < 0.001), MA/VAT (R = −0.605; p < 0.001), and MA/(SAT+VAT) (R = −0.416; p = 0.018). However, there was no association in NOb patients. This study demonstrated that SO patients had larger SAT and VAT than NOb patients. Hepatic fibrosis in SO positively correlated with body visceral fat composition in combination with BMI and AST level. These findings will be useful for understanding the relationship between the hepatic manifestation of fibrosis and body fat composition in sarcopenia and SO. MDPI 2023-06-26 /pmc/articles/PMC10342967/ /pubmed/37445314 http://dx.doi.org/10.3390/jcm12134279 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kim, Tae-Hoon Jeong, Chang-Won Lee, ChungSub Noh, SiHyeong Lim, Dong Wook Kim, Jin Woong Kim, Hyung Joong Kim, Youe Ree Association between Body Composition Contents and Hepatic Fibrosis in Sarcopenic Obesity |
title | Association between Body Composition Contents and Hepatic Fibrosis in Sarcopenic Obesity |
title_full | Association between Body Composition Contents and Hepatic Fibrosis in Sarcopenic Obesity |
title_fullStr | Association between Body Composition Contents and Hepatic Fibrosis in Sarcopenic Obesity |
title_full_unstemmed | Association between Body Composition Contents and Hepatic Fibrosis in Sarcopenic Obesity |
title_short | Association between Body Composition Contents and Hepatic Fibrosis in Sarcopenic Obesity |
title_sort | association between body composition contents and hepatic fibrosis in sarcopenic obesity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10342967/ https://www.ncbi.nlm.nih.gov/pubmed/37445314 http://dx.doi.org/10.3390/jcm12134279 |
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