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Defining an optimal cut-off point for reticulocyte hemoglobin as a marker for iron deficiency anemia: An ROC analysis

Reticulocyte hemoglobin (CHr) is a measure of the amount of hemoglobin in reticulocytes and a marker of cell hemoglobinization. In this study, we aimed to find the optimal cut-off point for reticulocyte hemoglobin to diagnose iron deficiency anemia using multiple methods. A total of 309 patients wer...

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Autores principales: Alzu’bi, Marah, Bawa’neh, Hisham, Alshorman, Alaa, Alrawabdeh, Jawad, Odeh, Nada, Hamadneh, Yazan, AlAdwan, Mai, Odeh, Mahmoud, Awidi, Abdalla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343059/
https://www.ncbi.nlm.nih.gov/pubmed/37440537
http://dx.doi.org/10.1371/journal.pone.0288505
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author Alzu’bi, Marah
Bawa’neh, Hisham
Alshorman, Alaa
Alrawabdeh, Jawad
Odeh, Nada
Hamadneh, Yazan
AlAdwan, Mai
Odeh, Mahmoud
Awidi, Abdalla
author_facet Alzu’bi, Marah
Bawa’neh, Hisham
Alshorman, Alaa
Alrawabdeh, Jawad
Odeh, Nada
Hamadneh, Yazan
AlAdwan, Mai
Odeh, Mahmoud
Awidi, Abdalla
author_sort Alzu’bi, Marah
collection PubMed
description Reticulocyte hemoglobin (CHr) is a measure of the amount of hemoglobin in reticulocytes and a marker of cell hemoglobinization. In this study, we aimed to find the optimal cut-off point for reticulocyte hemoglobin to diagnose iron deficiency anemia using multiple methods. A total of 309 patients were included. The median age at diagnosis was 54 years. Most were females (71.2%). 68% had iron deficiency anemia. Patients with IDA had significantly lower levels of CHr compared to those who had non-IDA (p < 0.0001). The optimal cut-off value of CHr for detecting IDA, determined using various methods, was 30.15 pg. This cut-off point had a sensitivity of 87.8% and a specificity of 77.7%. CHr showed a significant positive correlation with hemoglobin, mean corpuscular volume, serum iron, serum ferritin, and transferrin saturation and a significant negative correlation with total iron-binding capacity. CHr levels correlate with most established laboratory tests for IDA. It reliably detects IDA. Our results indicate the importance of CHr in diagnosing IDA, and that CHr should be used more widely in suspected cases of IDA since it is a cheap, fast, and reliable test.
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spelling pubmed-103430592023-07-14 Defining an optimal cut-off point for reticulocyte hemoglobin as a marker for iron deficiency anemia: An ROC analysis Alzu’bi, Marah Bawa’neh, Hisham Alshorman, Alaa Alrawabdeh, Jawad Odeh, Nada Hamadneh, Yazan AlAdwan, Mai Odeh, Mahmoud Awidi, Abdalla PLoS One Research Article Reticulocyte hemoglobin (CHr) is a measure of the amount of hemoglobin in reticulocytes and a marker of cell hemoglobinization. In this study, we aimed to find the optimal cut-off point for reticulocyte hemoglobin to diagnose iron deficiency anemia using multiple methods. A total of 309 patients were included. The median age at diagnosis was 54 years. Most were females (71.2%). 68% had iron deficiency anemia. Patients with IDA had significantly lower levels of CHr compared to those who had non-IDA (p < 0.0001). The optimal cut-off value of CHr for detecting IDA, determined using various methods, was 30.15 pg. This cut-off point had a sensitivity of 87.8% and a specificity of 77.7%. CHr showed a significant positive correlation with hemoglobin, mean corpuscular volume, serum iron, serum ferritin, and transferrin saturation and a significant negative correlation with total iron-binding capacity. CHr levels correlate with most established laboratory tests for IDA. It reliably detects IDA. Our results indicate the importance of CHr in diagnosing IDA, and that CHr should be used more widely in suspected cases of IDA since it is a cheap, fast, and reliable test. Public Library of Science 2023-07-13 /pmc/articles/PMC10343059/ /pubmed/37440537 http://dx.doi.org/10.1371/journal.pone.0288505 Text en © 2023 Alzu’bi et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Alzu’bi, Marah
Bawa’neh, Hisham
Alshorman, Alaa
Alrawabdeh, Jawad
Odeh, Nada
Hamadneh, Yazan
AlAdwan, Mai
Odeh, Mahmoud
Awidi, Abdalla
Defining an optimal cut-off point for reticulocyte hemoglobin as a marker for iron deficiency anemia: An ROC analysis
title Defining an optimal cut-off point for reticulocyte hemoglobin as a marker for iron deficiency anemia: An ROC analysis
title_full Defining an optimal cut-off point for reticulocyte hemoglobin as a marker for iron deficiency anemia: An ROC analysis
title_fullStr Defining an optimal cut-off point for reticulocyte hemoglobin as a marker for iron deficiency anemia: An ROC analysis
title_full_unstemmed Defining an optimal cut-off point for reticulocyte hemoglobin as a marker for iron deficiency anemia: An ROC analysis
title_short Defining an optimal cut-off point for reticulocyte hemoglobin as a marker for iron deficiency anemia: An ROC analysis
title_sort defining an optimal cut-off point for reticulocyte hemoglobin as a marker for iron deficiency anemia: an roc analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343059/
https://www.ncbi.nlm.nih.gov/pubmed/37440537
http://dx.doi.org/10.1371/journal.pone.0288505
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