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Study of serum level of kisspeptin and interferon-beta in genital wart patients

BACKGROUND: Researchers are interested in genital wart (GW) studies due to their increased incidence. In a single experimental research, virally infected mouse models showed elevated kisspeptin levels and low interferon levels. OBJECTIVE: The objective of the study was to evaluate the serum levels o...

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Autores principales: Eldeen Bazid, Heba Allah Saad, Marae, Alaa H., Tayel, Nermin, Zaid, Shereen G., Mostafa, Mohammed I., Abd El Gayed, Eman Masoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343131/
https://www.ncbi.nlm.nih.gov/pubmed/37457538
http://dx.doi.org/10.4103/ijstd.ijstd_93_22
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author Eldeen Bazid, Heba Allah Saad
Marae, Alaa H.
Tayel, Nermin
Zaid, Shereen G.
Mostafa, Mohammed I.
Abd El Gayed, Eman Masoud
author_facet Eldeen Bazid, Heba Allah Saad
Marae, Alaa H.
Tayel, Nermin
Zaid, Shereen G.
Mostafa, Mohammed I.
Abd El Gayed, Eman Masoud
author_sort Eldeen Bazid, Heba Allah Saad
collection PubMed
description BACKGROUND: Researchers are interested in genital wart (GW) studies due to their increased incidence. In a single experimental research, virally infected mouse models showed elevated kisspeptin levels and low interferon levels. OBJECTIVE: The objective of the study was to evaluate the serum levels of kisspeptin and interferon (INF)-beta in GW patients. PATIENTS AND METHODS: Forty patients with GWs and forty healthy participants of comparable age and sex as a control group were included in this case–control study. Serum levels of kisspeptin and IFN-beta were measured using ELISA during the period from December 2021 to April 2022. RESULTS: Kisspeptin was significantly higher among cases than controls, whereas IFN-beta level was lower among cases than controls (P < 0.001). There were no significant relations between kisspeptin and IFN-beta levels and the clinical data for the studied participants, and there was no significant correlation between both (P > 0.05). CONCLUSION: The reported increased kisspeptin level which was associated with decreased interferon-beta level in patients with GWs might indicate a new insight into viral infection pathogenesis. Further research including all steps in kisspeptin/G protein-coupled receptor 54 pathway is required. Targeted therapy for this pathway may be of value for those patients.
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spelling pubmed-103431312023-07-14 Study of serum level of kisspeptin and interferon-beta in genital wart patients Eldeen Bazid, Heba Allah Saad Marae, Alaa H. Tayel, Nermin Zaid, Shereen G. Mostafa, Mohammed I. Abd El Gayed, Eman Masoud Indian J Sex Transm Dis AIDS Original Article BACKGROUND: Researchers are interested in genital wart (GW) studies due to their increased incidence. In a single experimental research, virally infected mouse models showed elevated kisspeptin levels and low interferon levels. OBJECTIVE: The objective of the study was to evaluate the serum levels of kisspeptin and interferon (INF)-beta in GW patients. PATIENTS AND METHODS: Forty patients with GWs and forty healthy participants of comparable age and sex as a control group were included in this case–control study. Serum levels of kisspeptin and IFN-beta were measured using ELISA during the period from December 2021 to April 2022. RESULTS: Kisspeptin was significantly higher among cases than controls, whereas IFN-beta level was lower among cases than controls (P < 0.001). There were no significant relations between kisspeptin and IFN-beta levels and the clinical data for the studied participants, and there was no significant correlation between both (P > 0.05). CONCLUSION: The reported increased kisspeptin level which was associated with decreased interferon-beta level in patients with GWs might indicate a new insight into viral infection pathogenesis. Further research including all steps in kisspeptin/G protein-coupled receptor 54 pathway is required. Targeted therapy for this pathway may be of value for those patients. Wolters Kluwer - Medknow 2023 2023-06-06 /pmc/articles/PMC10343131/ /pubmed/37457538 http://dx.doi.org/10.4103/ijstd.ijstd_93_22 Text en Copyright: © 2023 Indian Journal of Sexually Transmitted Diseases and AIDS https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Eldeen Bazid, Heba Allah Saad
Marae, Alaa H.
Tayel, Nermin
Zaid, Shereen G.
Mostafa, Mohammed I.
Abd El Gayed, Eman Masoud
Study of serum level of kisspeptin and interferon-beta in genital wart patients
title Study of serum level of kisspeptin and interferon-beta in genital wart patients
title_full Study of serum level of kisspeptin and interferon-beta in genital wart patients
title_fullStr Study of serum level of kisspeptin and interferon-beta in genital wart patients
title_full_unstemmed Study of serum level of kisspeptin and interferon-beta in genital wart patients
title_short Study of serum level of kisspeptin and interferon-beta in genital wart patients
title_sort study of serum level of kisspeptin and interferon-beta in genital wart patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343131/
https://www.ncbi.nlm.nih.gov/pubmed/37457538
http://dx.doi.org/10.4103/ijstd.ijstd_93_22
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