Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor

Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for a variety of diseases. Recently, 7-hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide derivatives were shown to act at the CB2 receptor either as agonists or as inverse agonist...

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Detalles Bibliográficos
Autores principales: Mugnaini, Claudia, Kostrzewa, Magdalena, Casini, Marta, Kumar, Poulami, Catallo, Valeria, Allarà, Marco, Guastaferro, Laura, Brizzi, Antonella, Paolino, Marco, Tafi, Andrea, Kapatais, Christelos, Giorgi, Gianluca, Vacondio, Federica, Mor, Marco, Corelli, Federico, Ligresti, Alessia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343475/
https://www.ncbi.nlm.nih.gov/pubmed/37446625
http://dx.doi.org/10.3390/molecules28134958

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