DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes

We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. Th...

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Detalles Bibliográficos
Autores principales: Iglesias, Bernardo Almeida, Peranzoni, Níckolas Pippi, Faria, Sophia Iwersen, Trentin, Luana Belo, Schuch, André Passaglia, Chaves, Otávio Augusto, Bertoloni, Renan Ribeiro, Nikolaou, Sofia, de Oliveira, Kleber Thiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343509/
https://www.ncbi.nlm.nih.gov/pubmed/37446879
http://dx.doi.org/10.3390/molecules28135217
Descripción
Sumario:We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. The results suggest that the interaction of these compounds probably occurs via secondary interactions via external grooves (minor grooves) around the DNA macromolecule. Moreover, porphyrins containing peripheral Pd(II) or Pt(II) complexes (PdTThPor and PtTThPor) were able to promote photo-damage in the DNA.

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