DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes

We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. Th...

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Autores principales: Iglesias, Bernardo Almeida, Peranzoni, Níckolas Pippi, Faria, Sophia Iwersen, Trentin, Luana Belo, Schuch, André Passaglia, Chaves, Otávio Augusto, Bertoloni, Renan Ribeiro, Nikolaou, Sofia, de Oliveira, Kleber Thiago
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343509/
https://www.ncbi.nlm.nih.gov/pubmed/37446879
http://dx.doi.org/10.3390/molecules28135217
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author Iglesias, Bernardo Almeida
Peranzoni, Níckolas Pippi
Faria, Sophia Iwersen
Trentin, Luana Belo
Schuch, André Passaglia
Chaves, Otávio Augusto
Bertoloni, Renan Ribeiro
Nikolaou, Sofia
de Oliveira, Kleber Thiago
author_facet Iglesias, Bernardo Almeida
Peranzoni, Níckolas Pippi
Faria, Sophia Iwersen
Trentin, Luana Belo
Schuch, André Passaglia
Chaves, Otávio Augusto
Bertoloni, Renan Ribeiro
Nikolaou, Sofia
de Oliveira, Kleber Thiago
author_sort Iglesias, Bernardo Almeida
collection PubMed
description We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. The results suggest that the interaction of these compounds probably occurs via secondary interactions via external grooves (minor grooves) around the DNA macromolecule. Moreover, porphyrins containing peripheral Pd(II) or Pt(II) complexes (PdTThPor and PtTThPor) were able to promote photo-damage in the DNA.
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spelling pubmed-103435092023-07-14 DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes Iglesias, Bernardo Almeida Peranzoni, Níckolas Pippi Faria, Sophia Iwersen Trentin, Luana Belo Schuch, André Passaglia Chaves, Otávio Augusto Bertoloni, Renan Ribeiro Nikolaou, Sofia de Oliveira, Kleber Thiago Molecules Article We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. The results suggest that the interaction of these compounds probably occurs via secondary interactions via external grooves (minor grooves) around the DNA macromolecule. Moreover, porphyrins containing peripheral Pd(II) or Pt(II) complexes (PdTThPor and PtTThPor) were able to promote photo-damage in the DNA. MDPI 2023-07-05 /pmc/articles/PMC10343509/ /pubmed/37446879 http://dx.doi.org/10.3390/molecules28135217 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iglesias, Bernardo Almeida
Peranzoni, Níckolas Pippi
Faria, Sophia Iwersen
Trentin, Luana Belo
Schuch, André Passaglia
Chaves, Otávio Augusto
Bertoloni, Renan Ribeiro
Nikolaou, Sofia
de Oliveira, Kleber Thiago
DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes
title DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes
title_full DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes
title_fullStr DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes
title_full_unstemmed DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes
title_short DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes
title_sort dna-interactive and damage study with meso-tetra(2-thienyl)porphyrins coordinated with polypyridyl pd(ii) and pt(ii) complexes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343509/
https://www.ncbi.nlm.nih.gov/pubmed/37446879
http://dx.doi.org/10.3390/molecules28135217
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