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Pharmacological Activity of Cepharanthine

Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for human use and has been used in the clinic for more than 70 years. Cepharanthine has a variety of medicinal properties, includin...

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Autores principales: Liu, Ke, Hong, Bixia, Wang, Shuqi, Lou, Fuxing, You, Yecheng, Hu, Ruolan, Shafqat, Amna, Fan, Huahao, Tong, Yigang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343550/
https://www.ncbi.nlm.nih.gov/pubmed/37446681
http://dx.doi.org/10.3390/molecules28135019
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author Liu, Ke
Hong, Bixia
Wang, Shuqi
Lou, Fuxing
You, Yecheng
Hu, Ruolan
Shafqat, Amna
Fan, Huahao
Tong, Yigang
author_facet Liu, Ke
Hong, Bixia
Wang, Shuqi
Lou, Fuxing
You, Yecheng
Hu, Ruolan
Shafqat, Amna
Fan, Huahao
Tong, Yigang
author_sort Liu, Ke
collection PubMed
description Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for human use and has been used in the clinic for more than 70 years. Cepharanthine has a variety of medicinal properties, including signaling pathway inhibitory activities, immunomodulatory activities, and antiviral activities. Recently, cepharanthine has been confirmed to greatly inhibit SARS-CoV-2 infection. Therefore, we aimed to describe the pharmacological properties and mechanisms of cepharanthine, mainly including antitumor, anti-inflammatory, anti-pathogen activities, inhibition of bone resorption, treatment of alopecia, treatment of snake bite, and other activities. At the same time, we analyzed and summarized the potential antiviral mechanism of cepharanthine and concluded that one of the most important anti-viral mechanisms of cepharanthine may be the stability of plasma membrane fluidity. Additionally, we explained its safety and bioavailability, which provides evidence for cepharanthine as a potential drug for the treatment of a variety of diseases. Finally, we further discuss the potential new clinical applications of cepharanthine and provide direction for its future development.
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spelling pubmed-103435502023-07-14 Pharmacological Activity of Cepharanthine Liu, Ke Hong, Bixia Wang, Shuqi Lou, Fuxing You, Yecheng Hu, Ruolan Shafqat, Amna Fan, Huahao Tong, Yigang Molecules Review Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for human use and has been used in the clinic for more than 70 years. Cepharanthine has a variety of medicinal properties, including signaling pathway inhibitory activities, immunomodulatory activities, and antiviral activities. Recently, cepharanthine has been confirmed to greatly inhibit SARS-CoV-2 infection. Therefore, we aimed to describe the pharmacological properties and mechanisms of cepharanthine, mainly including antitumor, anti-inflammatory, anti-pathogen activities, inhibition of bone resorption, treatment of alopecia, treatment of snake bite, and other activities. At the same time, we analyzed and summarized the potential antiviral mechanism of cepharanthine and concluded that one of the most important anti-viral mechanisms of cepharanthine may be the stability of plasma membrane fluidity. Additionally, we explained its safety and bioavailability, which provides evidence for cepharanthine as a potential drug for the treatment of a variety of diseases. Finally, we further discuss the potential new clinical applications of cepharanthine and provide direction for its future development. MDPI 2023-06-27 /pmc/articles/PMC10343550/ /pubmed/37446681 http://dx.doi.org/10.3390/molecules28135019 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Ke
Hong, Bixia
Wang, Shuqi
Lou, Fuxing
You, Yecheng
Hu, Ruolan
Shafqat, Amna
Fan, Huahao
Tong, Yigang
Pharmacological Activity of Cepharanthine
title Pharmacological Activity of Cepharanthine
title_full Pharmacological Activity of Cepharanthine
title_fullStr Pharmacological Activity of Cepharanthine
title_full_unstemmed Pharmacological Activity of Cepharanthine
title_short Pharmacological Activity of Cepharanthine
title_sort pharmacological activity of cepharanthine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343550/
https://www.ncbi.nlm.nih.gov/pubmed/37446681
http://dx.doi.org/10.3390/molecules28135019
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