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(1-(4-(5-Phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-Bisfunctionalized 3- and 4-PEG: Synthesis and Photophysical Studies
Two new azaheterocycle-based bolas, such as (1-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-bisfunctionalized PEGs, were prepared via Cu-catalyzed click reaction between 2-(4-azidophenyl)-5-(aryl)-oxadiazole-1,3,4 and terminal ethynyls derived from PEG-3 and PEG-4...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343605/ https://www.ncbi.nlm.nih.gov/pubmed/37446917 http://dx.doi.org/10.3390/molecules28135256 |
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author | Mohammed, Mohammed S. Kovalev, Igor S. Slovesnova, Natalya V. Sadieva, Leila K. Platonov, Vadim A. Kim, Grigory A. Aluru, Rammohan Novikov, Alexander S. Taniya, Olga S. Charushin, Valery N. |
author_facet | Mohammed, Mohammed S. Kovalev, Igor S. Slovesnova, Natalya V. Sadieva, Leila K. Platonov, Vadim A. Kim, Grigory A. Aluru, Rammohan Novikov, Alexander S. Taniya, Olga S. Charushin, Valery N. |
author_sort | Mohammed, Mohammed S. |
collection | PubMed |
description | Two new azaheterocycle-based bolas, such as (1-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-bisfunctionalized PEGs, were prepared via Cu-catalyzed click reaction between 2-(4-azidophenyl)-5-(aryl)-oxadiazole-1,3,4 and terminal ethynyls derived from PEG-3 and PEG-4. Due to the presence of two heteroaromatic cores and a PEG linker, these bola molecules are considered as promising fluorescent chemosensors for electron-deficient species. As a result of a well-pronounced “turn-off” fluorescence response towards common nitro-explosive components, such as 2,4-dinitrotoluene (DNT) and 2,4,6-trinitrotoluene (TNT), hard-to-detect pentaerythritol tetranitrate (PETN), as well as Hg(2+) cation was observed. |
format | Online Article Text |
id | pubmed-10343605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103436052023-07-14 (1-(4-(5-Phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-Bisfunctionalized 3- and 4-PEG: Synthesis and Photophysical Studies Mohammed, Mohammed S. Kovalev, Igor S. Slovesnova, Natalya V. Sadieva, Leila K. Platonov, Vadim A. Kim, Grigory A. Aluru, Rammohan Novikov, Alexander S. Taniya, Olga S. Charushin, Valery N. Molecules Article Two new azaheterocycle-based bolas, such as (1-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-bisfunctionalized PEGs, were prepared via Cu-catalyzed click reaction between 2-(4-azidophenyl)-5-(aryl)-oxadiazole-1,3,4 and terminal ethynyls derived from PEG-3 and PEG-4. Due to the presence of two heteroaromatic cores and a PEG linker, these bola molecules are considered as promising fluorescent chemosensors for electron-deficient species. As a result of a well-pronounced “turn-off” fluorescence response towards common nitro-explosive components, such as 2,4-dinitrotoluene (DNT) and 2,4,6-trinitrotoluene (TNT), hard-to-detect pentaerythritol tetranitrate (PETN), as well as Hg(2+) cation was observed. MDPI 2023-07-06 /pmc/articles/PMC10343605/ /pubmed/37446917 http://dx.doi.org/10.3390/molecules28135256 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mohammed, Mohammed S. Kovalev, Igor S. Slovesnova, Natalya V. Sadieva, Leila K. Platonov, Vadim A. Kim, Grigory A. Aluru, Rammohan Novikov, Alexander S. Taniya, Olga S. Charushin, Valery N. (1-(4-(5-Phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-Bisfunctionalized 3- and 4-PEG: Synthesis and Photophysical Studies |
title | (1-(4-(5-Phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-Bisfunctionalized 3- and 4-PEG: Synthesis and Photophysical Studies |
title_full | (1-(4-(5-Phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-Bisfunctionalized 3- and 4-PEG: Synthesis and Photophysical Studies |
title_fullStr | (1-(4-(5-Phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-Bisfunctionalized 3- and 4-PEG: Synthesis and Photophysical Studies |
title_full_unstemmed | (1-(4-(5-Phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-Bisfunctionalized 3- and 4-PEG: Synthesis and Photophysical Studies |
title_short | (1-(4-(5-Phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-Bisfunctionalized 3- and 4-PEG: Synthesis and Photophysical Studies |
title_sort | (1-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1h-1,2,3-triazol-4-yl)-methylenyls α,ω-bisfunctionalized 3- and 4-peg: synthesis and photophysical studies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343605/ https://www.ncbi.nlm.nih.gov/pubmed/37446917 http://dx.doi.org/10.3390/molecules28135256 |
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