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Structural Modification Endows Small-Molecular SN38 Derivatives with Multifaceted Functions

As a camptothecin derivative, 7-ethyl-10-hydroxycamptothecin (SN38) combats cancer by inhibiting topoisomerase I. SN38 is one of the most active compounds among camptothecin derivatives. In addition, SN38 is also a theranostic reagent due to its intrinsic fluorescence. However, the poor water solubi...

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Detalles Bibliográficos
Autores principales: Dai, Yi, Qian, Meng, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343627/
https://www.ncbi.nlm.nih.gov/pubmed/37446591
http://dx.doi.org/10.3390/molecules28134931