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Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil
Background: Few studies have evaluated the association between diet-related inflammation and gastric adenocarcinoma (GA) and evidence is scarce in Brazil. This study evaluated the association between a pro-inflammatory diet and GA. Methods: A multicenter case–control study was conducted in Brazil. A...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343640/ https://www.ncbi.nlm.nih.gov/pubmed/37447193 http://dx.doi.org/10.3390/nu15132867 |
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author | Silva, Alex Richard Costa Guandalini, Valdete Regina Pereira, Taísa Sabrina Silva Zhao, Longgang Wirth, Michael D. Hébert, James R. Fernandes, Gisele Aparecida de Assumpção, Paulo Pimentel Barbosa, Mônica Santiago Curado, Maria Paula |
author_facet | Silva, Alex Richard Costa Guandalini, Valdete Regina Pereira, Taísa Sabrina Silva Zhao, Longgang Wirth, Michael D. Hébert, James R. Fernandes, Gisele Aparecida de Assumpção, Paulo Pimentel Barbosa, Mônica Santiago Curado, Maria Paula |
author_sort | Silva, Alex Richard Costa |
collection | PubMed |
description | Background: Few studies have evaluated the association between diet-related inflammation and gastric adenocarcinoma (GA) and evidence is scarce in Brazil. This study evaluated the association between a pro-inflammatory diet and GA. Methods: A multicenter case–control study was conducted in Brazil. A total of 1645 participants—492 cases, 377 endoscopy controls, and 776 hospital controls—were included. Energy-adjusted Dietary Inflammatory Index (E-DII(TM)) scores were derived from a validated food frequency questionnaire. We used binary and multinomial logistic regression models for the analysis of total GA, and its subtypes (cardia and non-cardia, intestinal, and diffuse histological subtypes). Results: In cases versus endoscopy controls, a pro-inflammatory diet, estimated by higher E-DII scores, was associated with a higher risk GA (OR(Q4vsQ1): 2.60, 1.16–5.70), of non-cardia GA (OR: 2.90, 1.06–7.82), and diffuse subtype (OR: 3.93, 1.59–9.70). In cases versus hospital controls, higher E-DII scores were associated with a higher risk of GA (OR: 2.70, 1.60–4.54), of cardia GA (OR: 3.31, 1.32–8.24), non-cardia GA (OR: 2.97, 1.64–5.39), and both intestinal (OR: 2.82, 1.38–5.74) and diffuse GA (OR: 2.50, 1.54–5.11) subtypes. Conclusions: This study provides evidence that a pro-inflammatory diet is associated with an increased risk of GA in Brazil. E-DII requires the inclusion of sodium due to its importance in carcinogenesis. |
format | Online Article Text |
id | pubmed-10343640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103436402023-07-14 Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil Silva, Alex Richard Costa Guandalini, Valdete Regina Pereira, Taísa Sabrina Silva Zhao, Longgang Wirth, Michael D. Hébert, James R. Fernandes, Gisele Aparecida de Assumpção, Paulo Pimentel Barbosa, Mônica Santiago Curado, Maria Paula Nutrients Article Background: Few studies have evaluated the association between diet-related inflammation and gastric adenocarcinoma (GA) and evidence is scarce in Brazil. This study evaluated the association between a pro-inflammatory diet and GA. Methods: A multicenter case–control study was conducted in Brazil. A total of 1645 participants—492 cases, 377 endoscopy controls, and 776 hospital controls—were included. Energy-adjusted Dietary Inflammatory Index (E-DII(TM)) scores were derived from a validated food frequency questionnaire. We used binary and multinomial logistic regression models for the analysis of total GA, and its subtypes (cardia and non-cardia, intestinal, and diffuse histological subtypes). Results: In cases versus endoscopy controls, a pro-inflammatory diet, estimated by higher E-DII scores, was associated with a higher risk GA (OR(Q4vsQ1): 2.60, 1.16–5.70), of non-cardia GA (OR: 2.90, 1.06–7.82), and diffuse subtype (OR: 3.93, 1.59–9.70). In cases versus hospital controls, higher E-DII scores were associated with a higher risk of GA (OR: 2.70, 1.60–4.54), of cardia GA (OR: 3.31, 1.32–8.24), non-cardia GA (OR: 2.97, 1.64–5.39), and both intestinal (OR: 2.82, 1.38–5.74) and diffuse GA (OR: 2.50, 1.54–5.11) subtypes. Conclusions: This study provides evidence that a pro-inflammatory diet is associated with an increased risk of GA in Brazil. E-DII requires the inclusion of sodium due to its importance in carcinogenesis. MDPI 2023-06-24 /pmc/articles/PMC10343640/ /pubmed/37447193 http://dx.doi.org/10.3390/nu15132867 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Silva, Alex Richard Costa Guandalini, Valdete Regina Pereira, Taísa Sabrina Silva Zhao, Longgang Wirth, Michael D. Hébert, James R. Fernandes, Gisele Aparecida de Assumpção, Paulo Pimentel Barbosa, Mônica Santiago Curado, Maria Paula Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil |
title | Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil |
title_full | Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil |
title_fullStr | Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil |
title_full_unstemmed | Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil |
title_short | Association between Dietary Inflammatory Index and Gastric Adenocarcinoma: A Multicenter Case-Control Study in Brazil |
title_sort | association between dietary inflammatory index and gastric adenocarcinoma: a multicenter case-control study in brazil |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343640/ https://www.ncbi.nlm.nih.gov/pubmed/37447193 http://dx.doi.org/10.3390/nu15132867 |
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