Phragmalin-Type Limonoids from the Fruits of Chukrasia tabularis and Their Anti-Inflammatory Activity

Phytochemical investigation on the fruits of C. tabularis led to the isolation of five new phragmalin-type limonoids (1–5) and four known ones (6–9). The structures of the new compounds 1–5, named chuktabamalins A–E, were elucidated via spectroscopic techniques (HRESIMS, 1D and 2D NMR) and were comp...

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Detalles Bibliográficos
Autores principales: Dai, Shujun, Wu, Yuzhen, Xin, Xiujuan, An, Faliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343657/
https://www.ncbi.nlm.nih.gov/pubmed/37446797
http://dx.doi.org/10.3390/molecules28135136
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author Dai, Shujun
Wu, Yuzhen
Xin, Xiujuan
An, Faliang
author_facet Dai, Shujun
Wu, Yuzhen
Xin, Xiujuan
An, Faliang
author_sort Dai, Shujun
collection PubMed
description Phytochemical investigation on the fruits of C. tabularis led to the isolation of five new phragmalin-type limonoids (1–5) and four known ones (6–9). The structures of the new compounds 1–5, named chuktabamalins A–E, were elucidated via spectroscopic techniques (HRESIMS, 1D and 2D NMR) and were comparable with the literature data of known compounds. In addition, new compounds were evaluated for in vitro anti-inflammatory activity. Compounds 1, 2, 3 and 5 showed moderate anti-inflammatory activity with IC(50) values of 21.72 ± 2.79, 23.29 ± 1.00, 47.08 ± 3.47 and 66.67 ± 2.89 μM, respectively.
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spelling pubmed-103436572023-07-14 Phragmalin-Type Limonoids from the Fruits of Chukrasia tabularis and Their Anti-Inflammatory Activity Dai, Shujun Wu, Yuzhen Xin, Xiujuan An, Faliang Molecules Communication Phytochemical investigation on the fruits of C. tabularis led to the isolation of five new phragmalin-type limonoids (1–5) and four known ones (6–9). The structures of the new compounds 1–5, named chuktabamalins A–E, were elucidated via spectroscopic techniques (HRESIMS, 1D and 2D NMR) and were comparable with the literature data of known compounds. In addition, new compounds were evaluated for in vitro anti-inflammatory activity. Compounds 1, 2, 3 and 5 showed moderate anti-inflammatory activity with IC(50) values of 21.72 ± 2.79, 23.29 ± 1.00, 47.08 ± 3.47 and 66.67 ± 2.89 μM, respectively. MDPI 2023-06-30 /pmc/articles/PMC10343657/ /pubmed/37446797 http://dx.doi.org/10.3390/molecules28135136 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Dai, Shujun
Wu, Yuzhen
Xin, Xiujuan
An, Faliang
Phragmalin-Type Limonoids from the Fruits of Chukrasia tabularis and Their Anti-Inflammatory Activity
title Phragmalin-Type Limonoids from the Fruits of Chukrasia tabularis and Their Anti-Inflammatory Activity
title_full Phragmalin-Type Limonoids from the Fruits of Chukrasia tabularis and Their Anti-Inflammatory Activity
title_fullStr Phragmalin-Type Limonoids from the Fruits of Chukrasia tabularis and Their Anti-Inflammatory Activity
title_full_unstemmed Phragmalin-Type Limonoids from the Fruits of Chukrasia tabularis and Their Anti-Inflammatory Activity
title_short Phragmalin-Type Limonoids from the Fruits of Chukrasia tabularis and Their Anti-Inflammatory Activity
title_sort phragmalin-type limonoids from the fruits of chukrasia tabularis and their anti-inflammatory activity
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343657/
https://www.ncbi.nlm.nih.gov/pubmed/37446797
http://dx.doi.org/10.3390/molecules28135136
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