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Effect of Milk Fat Globule Membrane- and Protein-Containing Snack Product on Physical Performance of Older Women—A Randomized Controlled Trial

Introduction: Sarcopenia is common in people 70+ years of age, and its prevalence increases with further aging. Insufficient energy and protein intake accelerates muscle loss, whereas sufficient protein intake and milk fat globule membrane (MFGM) may suppress age-associated deterioration of muscle m...

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Autores principales: Jyväkorpi, Satu K., Niskanen, Riikka T., Markkanen, Marianna, Salminen, Karoliina, Sibakov, Timo, Lehtonen, Kaity-Marin, Kunvik, Susanna, Pitkala, Kaisu H., Turpeinen, Anu M., Suominen, Merja H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343882/
https://www.ncbi.nlm.nih.gov/pubmed/37447248
http://dx.doi.org/10.3390/nu15132922
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author Jyväkorpi, Satu K.
Niskanen, Riikka T.
Markkanen, Marianna
Salminen, Karoliina
Sibakov, Timo
Lehtonen, Kaity-Marin
Kunvik, Susanna
Pitkala, Kaisu H.
Turpeinen, Anu M.
Suominen, Merja H.
author_facet Jyväkorpi, Satu K.
Niskanen, Riikka T.
Markkanen, Marianna
Salminen, Karoliina
Sibakov, Timo
Lehtonen, Kaity-Marin
Kunvik, Susanna
Pitkala, Kaisu H.
Turpeinen, Anu M.
Suominen, Merja H.
author_sort Jyväkorpi, Satu K.
collection PubMed
description Introduction: Sarcopenia is common in people 70+ years of age, and its prevalence increases with further aging. Insufficient energy and protein intake accelerates muscle loss, whereas sufficient protein intake and milk fat globule membrane (MFGM) may suppress age-associated deterioration of muscle mass and strength. Our objective was to test whether a snack product high in MFGM and protein would improve physical performance in older women. Methods: In this 12-week randomized controlled trial, women ≥ 70 years, with protein intake < 1.2 g/body weight (BW) kg/day (d), were randomized into intervention (n = 51) and control (n = 50) groups. The intervention group received a daily snack product containing ≥ 23 g of milk protein and 3.6–3.9 g of MFGM. Both groups were advised to perform a five-movement exercise routine. The primary outcome was the change in the five-time-sit-to-stand test between the groups. Secondary outcomes included changes in physical performance, cognition, hand grip strength, and health-related quality of life. Results: The change in the five-time-sit-to-stand test did not differ between the intervention and the control groups. The change in the total Short Physical Performance Battery score differed significantly, favoring the intervention group (p = 0.020), and the balance test showed the largest difference. Protein intake increased significantly in the intervention group (+14 g) compared to the control group (+2 g). No other significant changes were observed. Conclusions: Our results indicate that the combination of MFGM and protein may improve the physical performance-related balance of older women.
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spelling pubmed-103438822023-07-14 Effect of Milk Fat Globule Membrane- and Protein-Containing Snack Product on Physical Performance of Older Women—A Randomized Controlled Trial Jyväkorpi, Satu K. Niskanen, Riikka T. Markkanen, Marianna Salminen, Karoliina Sibakov, Timo Lehtonen, Kaity-Marin Kunvik, Susanna Pitkala, Kaisu H. Turpeinen, Anu M. Suominen, Merja H. Nutrients Article Introduction: Sarcopenia is common in people 70+ years of age, and its prevalence increases with further aging. Insufficient energy and protein intake accelerates muscle loss, whereas sufficient protein intake and milk fat globule membrane (MFGM) may suppress age-associated deterioration of muscle mass and strength. Our objective was to test whether a snack product high in MFGM and protein would improve physical performance in older women. Methods: In this 12-week randomized controlled trial, women ≥ 70 years, with protein intake < 1.2 g/body weight (BW) kg/day (d), were randomized into intervention (n = 51) and control (n = 50) groups. The intervention group received a daily snack product containing ≥ 23 g of milk protein and 3.6–3.9 g of MFGM. Both groups were advised to perform a five-movement exercise routine. The primary outcome was the change in the five-time-sit-to-stand test between the groups. Secondary outcomes included changes in physical performance, cognition, hand grip strength, and health-related quality of life. Results: The change in the five-time-sit-to-stand test did not differ between the intervention and the control groups. The change in the total Short Physical Performance Battery score differed significantly, favoring the intervention group (p = 0.020), and the balance test showed the largest difference. Protein intake increased significantly in the intervention group (+14 g) compared to the control group (+2 g). No other significant changes were observed. Conclusions: Our results indicate that the combination of MFGM and protein may improve the physical performance-related balance of older women. MDPI 2023-06-27 /pmc/articles/PMC10343882/ /pubmed/37447248 http://dx.doi.org/10.3390/nu15132922 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jyväkorpi, Satu K.
Niskanen, Riikka T.
Markkanen, Marianna
Salminen, Karoliina
Sibakov, Timo
Lehtonen, Kaity-Marin
Kunvik, Susanna
Pitkala, Kaisu H.
Turpeinen, Anu M.
Suominen, Merja H.
Effect of Milk Fat Globule Membrane- and Protein-Containing Snack Product on Physical Performance of Older Women—A Randomized Controlled Trial
title Effect of Milk Fat Globule Membrane- and Protein-Containing Snack Product on Physical Performance of Older Women—A Randomized Controlled Trial
title_full Effect of Milk Fat Globule Membrane- and Protein-Containing Snack Product on Physical Performance of Older Women—A Randomized Controlled Trial
title_fullStr Effect of Milk Fat Globule Membrane- and Protein-Containing Snack Product on Physical Performance of Older Women—A Randomized Controlled Trial
title_full_unstemmed Effect of Milk Fat Globule Membrane- and Protein-Containing Snack Product on Physical Performance of Older Women—A Randomized Controlled Trial
title_short Effect of Milk Fat Globule Membrane- and Protein-Containing Snack Product on Physical Performance of Older Women—A Randomized Controlled Trial
title_sort effect of milk fat globule membrane- and protein-containing snack product on physical performance of older women—a randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10343882/
https://www.ncbi.nlm.nih.gov/pubmed/37447248
http://dx.doi.org/10.3390/nu15132922
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