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The influence of sex on the treatment of postural tachycardia syndrome in children

There are differences in postural tachycardia syndrome (POTS) incidence and manifestations in children between the sexes. However, there is limited evidence on how the gender affects the prognosis of POTS in children. This study is aimed at exploring the differences between the sexes regarding the p...

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Autores principales: Peng, Yali, Wang, Shuo, Zou, Runmei, Cai, Hong, Zhang, Juan, Wang, Yuwen, Wang, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344500/
https://www.ncbi.nlm.nih.gov/pubmed/37443510
http://dx.doi.org/10.1097/MD.0000000000033951
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author Peng, Yali
Wang, Shuo
Zou, Runmei
Cai, Hong
Zhang, Juan
Wang, Yuwen
Wang, Cheng
author_facet Peng, Yali
Wang, Shuo
Zou, Runmei
Cai, Hong
Zhang, Juan
Wang, Yuwen
Wang, Cheng
author_sort Peng, Yali
collection PubMed
description There are differences in postural tachycardia syndrome (POTS) incidence and manifestations in children between the sexes. However, there is limited evidence on how the gender affects the prognosis of POTS in children. This study is aimed at exploring the differences between the sexes regarding the prognosis of children with POTS. A retrospective study was conducted on children (n = 53; aged 6–14 years) who were diagnosed with POTS. All the POTS patients were given health education and autonomic function training, their water and salt intake was increased (oral rehydration salt III, 250 mL, Bid), and they were administered oral metoprolol (1 mg/kg per day) for 3 months. The prognosis was defined by the head-up tilt test results after treatment. It was observed that male and female children exhibited different trends in POTS prognosis. Further, the sex showed a stable independent effect on prognostic in children with POTS. To elaborate, females had a 503% increased risk of poor prognosis compared to males. We hence hypothesize that there is an association between the sex and the POTS prognosis in children. Female patients have a significantly higher risk of poor prognosis compared to males. A slight increase in the dose of oral rehydration salt could help lower the risk of poor prognosis in children with POTS. A higher absorption of total metoprolol, lower local concentrations, and slower metabolic excretion are documented in research in female POTS patients during treatment. It is recommended that the optimal dose of metoprolol should be lowered in female children undergoing treatment, to limit the risk of poor prognosis.
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spelling pubmed-103445002023-07-14 The influence of sex on the treatment of postural tachycardia syndrome in children Peng, Yali Wang, Shuo Zou, Runmei Cai, Hong Zhang, Juan Wang, Yuwen Wang, Cheng Medicine (Baltimore) 3400 There are differences in postural tachycardia syndrome (POTS) incidence and manifestations in children between the sexes. However, there is limited evidence on how the gender affects the prognosis of POTS in children. This study is aimed at exploring the differences between the sexes regarding the prognosis of children with POTS. A retrospective study was conducted on children (n = 53; aged 6–14 years) who were diagnosed with POTS. All the POTS patients were given health education and autonomic function training, their water and salt intake was increased (oral rehydration salt III, 250 mL, Bid), and they were administered oral metoprolol (1 mg/kg per day) for 3 months. The prognosis was defined by the head-up tilt test results after treatment. It was observed that male and female children exhibited different trends in POTS prognosis. Further, the sex showed a stable independent effect on prognostic in children with POTS. To elaborate, females had a 503% increased risk of poor prognosis compared to males. We hence hypothesize that there is an association between the sex and the POTS prognosis in children. Female patients have a significantly higher risk of poor prognosis compared to males. A slight increase in the dose of oral rehydration salt could help lower the risk of poor prognosis in children with POTS. A higher absorption of total metoprolol, lower local concentrations, and slower metabolic excretion are documented in research in female POTS patients during treatment. It is recommended that the optimal dose of metoprolol should be lowered in female children undergoing treatment, to limit the risk of poor prognosis. Lippincott Williams & Wilkins 2023-07-14 /pmc/articles/PMC10344500/ /pubmed/37443510 http://dx.doi.org/10.1097/MD.0000000000033951 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 3400
Peng, Yali
Wang, Shuo
Zou, Runmei
Cai, Hong
Zhang, Juan
Wang, Yuwen
Wang, Cheng
The influence of sex on the treatment of postural tachycardia syndrome in children
title The influence of sex on the treatment of postural tachycardia syndrome in children
title_full The influence of sex on the treatment of postural tachycardia syndrome in children
title_fullStr The influence of sex on the treatment of postural tachycardia syndrome in children
title_full_unstemmed The influence of sex on the treatment of postural tachycardia syndrome in children
title_short The influence of sex on the treatment of postural tachycardia syndrome in children
title_sort influence of sex on the treatment of postural tachycardia syndrome in children
topic 3400
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344500/
https://www.ncbi.nlm.nih.gov/pubmed/37443510
http://dx.doi.org/10.1097/MD.0000000000033951
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