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The role of anesthetic drug and technique in endothelial glycocalyx: A narrative review
The level of endothelial glycocalyx (EG) shedding is associated with morbidity and mortality, and vascular endothelial barrier dysfunction is one of the pivotal clinical problems faced by critically ill patients, so research on the protective effects of EG is of great clinical significance for the t...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344525/ https://www.ncbi.nlm.nih.gov/pubmed/37443493 http://dx.doi.org/10.1097/MD.0000000000034265 |
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author | Li, Xuechao Zeng, Sisi Wan, Jixiang Yang, Zhen Wang, Fangjun |
author_facet | Li, Xuechao Zeng, Sisi Wan, Jixiang Yang, Zhen Wang, Fangjun |
author_sort | Li, Xuechao |
collection | PubMed |
description | The level of endothelial glycocalyx (EG) shedding is associated with morbidity and mortality, and vascular endothelial barrier dysfunction is one of the pivotal clinical problems faced by critically ill patients, so research on the protective effects of EG is of great clinical significance for the treatment of critically ill diseases. Studies have illustrated that clinical anesthesia has different degrees of effects on vascular EG. Therefore, we reviewed the effects of distinct anesthesia methods and diverse anesthetic drugs on EG, aiming to provide a brief summary of what we know now, and to discuss possible future directions for investigations in this area. So as to provide a theoretical basis for future research on potential EG-positive drugs and targets, to minimize perioperative complications and improve the prognosis of surgical patients. |
format | Online Article Text |
id | pubmed-10344525 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-103445252023-07-14 The role of anesthetic drug and technique in endothelial glycocalyx: A narrative review Li, Xuechao Zeng, Sisi Wan, Jixiang Yang, Zhen Wang, Fangjun Medicine (Baltimore) 3300 The level of endothelial glycocalyx (EG) shedding is associated with morbidity and mortality, and vascular endothelial barrier dysfunction is one of the pivotal clinical problems faced by critically ill patients, so research on the protective effects of EG is of great clinical significance for the treatment of critically ill diseases. Studies have illustrated that clinical anesthesia has different degrees of effects on vascular EG. Therefore, we reviewed the effects of distinct anesthesia methods and diverse anesthetic drugs on EG, aiming to provide a brief summary of what we know now, and to discuss possible future directions for investigations in this area. So as to provide a theoretical basis for future research on potential EG-positive drugs and targets, to minimize perioperative complications and improve the prognosis of surgical patients. Lippincott Williams & Wilkins 2023-07-14 /pmc/articles/PMC10344525/ /pubmed/37443493 http://dx.doi.org/10.1097/MD.0000000000034265 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 3300 Li, Xuechao Zeng, Sisi Wan, Jixiang Yang, Zhen Wang, Fangjun The role of anesthetic drug and technique in endothelial glycocalyx: A narrative review |
title | The role of anesthetic drug and technique in endothelial glycocalyx: A narrative review |
title_full | The role of anesthetic drug and technique in endothelial glycocalyx: A narrative review |
title_fullStr | The role of anesthetic drug and technique in endothelial glycocalyx: A narrative review |
title_full_unstemmed | The role of anesthetic drug and technique in endothelial glycocalyx: A narrative review |
title_short | The role of anesthetic drug and technique in endothelial glycocalyx: A narrative review |
title_sort | role of anesthetic drug and technique in endothelial glycocalyx: a narrative review |
topic | 3300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344525/ https://www.ncbi.nlm.nih.gov/pubmed/37443493 http://dx.doi.org/10.1097/MD.0000000000034265 |
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