Phosphodiesterase 8 governs cAMP/PKA-dependent reduction of L-type calcium current in human atrial fibrillation: a novel arrhythmogenic mechanism

AIMS: Atrial fibrillation (AF) is associated with altered cAMP/PKA signaling and an AF-promoting reduction of L-type Ca(2+)-current (I(Ca,L)), the mechanisms of which are poorly understood. Cyclic-nucleotide phosphodiesterases (PDEs) degrade cAMP and regulate PKA-dependent phosphorylation of key cal...

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Detalles Bibliográficos
Autores principales: Grammatika Pavlidou, Nefeli, Dobrev, Shokoufeh, Beneke, Kira, Reinhardt, Franziska, Pecha, Simon, Jacquet, Eric, Abu-Taha, Issam H, Schmidt, Constanze, Voigt, Niels, Kamler, Markus, Schnabel, Renate B, Baczkó, Istvan, Garnier, Anne, Reichenspurner, Hermann, Nikolaev, Viacheslav O, Dobrev, Dobromir, Molina, Cristina E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344654/
https://www.ncbi.nlm.nih.gov/pubmed/36810794
http://dx.doi.org/10.1093/eurheartj/ehad086

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