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How acute myeloid leukemia (AML) escapes from FMS-related tyrosine kinase 3 (FLT3) inhibitors? Still an overrated complication?

FMS-related tyrosine kinase 3 (FLT3) mutations, present in about 25%-30% of acute myeloid leukemia (AML) patients, constitute one of the most frequently detected mutations in these patients. The binding of FLT3L to FLT3 activates the phosphatidylinositol 3-kinase (PI3K) and RAS pathways, producing i...

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Detalles Bibliográficos
Autores principales:	Perrone, Salvatore, Ottone, Tiziana, Zhdanovskaya, Nadezda, Molica, Matteo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	OAE Publishing Inc. 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344728/ https://www.ncbi.nlm.nih.gov/pubmed/37457126 http://dx.doi.org/10.20517/cdr.2022.130

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