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Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer

Despite intensive efforts and refined techniques, overall survival in HPV-negative head and neck cancer remains poor. Robust immune priming is required to elicit a strong and durable antitumor immune response in immunologically cold and excluded tumors like HPV-negative head and neck cancer. This re...

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Autor principal: Benavente, Sergi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OAE Publishing Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344731/
https://www.ncbi.nlm.nih.gov/pubmed/37457128
http://dx.doi.org/10.20517/cdr.2022.141
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author Benavente, Sergi
author_facet Benavente, Sergi
author_sort Benavente, Sergi
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description Despite intensive efforts and refined techniques, overall survival in HPV-negative head and neck cancer remains poor. Robust immune priming is required to elicit a strong and durable antitumor immune response in immunologically cold and excluded tumors like HPV-negative head and neck cancer. This review highlights how the tumor microenvironment could be affected by different immune and stromal cell types, weighs the need to integrate metabolic regulation of the tumor microenvironment into cancer treatment strategies and summarizes the emerging clinical applicability of personalized immunotherapeutic strategies in HPV-negative head and neck cancer.
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spelling pubmed-103447312023-07-15 Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer Benavente, Sergi Cancer Drug Resist Review Despite intensive efforts and refined techniques, overall survival in HPV-negative head and neck cancer remains poor. Robust immune priming is required to elicit a strong and durable antitumor immune response in immunologically cold and excluded tumors like HPV-negative head and neck cancer. This review highlights how the tumor microenvironment could be affected by different immune and stromal cell types, weighs the need to integrate metabolic regulation of the tumor microenvironment into cancer treatment strategies and summarizes the emerging clinical applicability of personalized immunotherapeutic strategies in HPV-negative head and neck cancer. OAE Publishing Inc. 2023-05-30 /pmc/articles/PMC10344731/ /pubmed/37457128 http://dx.doi.org/10.20517/cdr.2022.141 Text en © The Author(s) 2023. https://creativecommons.org/licenses/by/4.0/© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Review
Benavente, Sergi
Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer
title Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer
title_full Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer
title_fullStr Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer
title_full_unstemmed Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer
title_short Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer
title_sort remodeling the tumor microenvironment to overcome treatment resistance in hpv-negative head and neck cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344731/
https://www.ncbi.nlm.nih.gov/pubmed/37457128
http://dx.doi.org/10.20517/cdr.2022.141
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