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Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer
Despite intensive efforts and refined techniques, overall survival in HPV-negative head and neck cancer remains poor. Robust immune priming is required to elicit a strong and durable antitumor immune response in immunologically cold and excluded tumors like HPV-negative head and neck cancer. This re...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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OAE Publishing Inc.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344731/ https://www.ncbi.nlm.nih.gov/pubmed/37457128 http://dx.doi.org/10.20517/cdr.2022.141 |
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author | Benavente, Sergi |
author_facet | Benavente, Sergi |
author_sort | Benavente, Sergi |
collection | PubMed |
description | Despite intensive efforts and refined techniques, overall survival in HPV-negative head and neck cancer remains poor. Robust immune priming is required to elicit a strong and durable antitumor immune response in immunologically cold and excluded tumors like HPV-negative head and neck cancer. This review highlights how the tumor microenvironment could be affected by different immune and stromal cell types, weighs the need to integrate metabolic regulation of the tumor microenvironment into cancer treatment strategies and summarizes the emerging clinical applicability of personalized immunotherapeutic strategies in HPV-negative head and neck cancer. |
format | Online Article Text |
id | pubmed-10344731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | OAE Publishing Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103447312023-07-15 Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer Benavente, Sergi Cancer Drug Resist Review Despite intensive efforts and refined techniques, overall survival in HPV-negative head and neck cancer remains poor. Robust immune priming is required to elicit a strong and durable antitumor immune response in immunologically cold and excluded tumors like HPV-negative head and neck cancer. This review highlights how the tumor microenvironment could be affected by different immune and stromal cell types, weighs the need to integrate metabolic regulation of the tumor microenvironment into cancer treatment strategies and summarizes the emerging clinical applicability of personalized immunotherapeutic strategies in HPV-negative head and neck cancer. OAE Publishing Inc. 2023-05-30 /pmc/articles/PMC10344731/ /pubmed/37457128 http://dx.doi.org/10.20517/cdr.2022.141 Text en © The Author(s) 2023. https://creativecommons.org/licenses/by/4.0/© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Benavente, Sergi Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer |
title | Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer |
title_full | Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer |
title_fullStr | Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer |
title_full_unstemmed | Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer |
title_short | Remodeling the tumor microenvironment to overcome treatment resistance in HPV-negative head and neck cancer |
title_sort | remodeling the tumor microenvironment to overcome treatment resistance in hpv-negative head and neck cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344731/ https://www.ncbi.nlm.nih.gov/pubmed/37457128 http://dx.doi.org/10.20517/cdr.2022.141 |
work_keys_str_mv | AT benaventesergi remodelingthetumormicroenvironmenttoovercometreatmentresistanceinhpvnegativeheadandneckcancer |