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Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft

Transmission of a malignancy from a donor’s organ to the recipient of the graft is a rare event, though it is a severe complication that can result in a poor outcome. Usually, immunosuppressive therapy is discontinued and the allograft is removed. However, treatment of patients with the disseminated...

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Autores principales: Kiselevskiy, Mikhail V., Gromova, Elena G., Kozlov, Nikolay A., Bezhanova, Svetlana D., Shubina, Irina Zh.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Open Exploration Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344895/
https://www.ncbi.nlm.nih.gov/pubmed/37455824
http://dx.doi.org/10.37349/etat.2023.00148
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author Kiselevskiy, Mikhail V.
Gromova, Elena G.
Kozlov, Nikolay A.
Bezhanova, Svetlana D.
Shubina, Irina Zh.
author_facet Kiselevskiy, Mikhail V.
Gromova, Elena G.
Kozlov, Nikolay A.
Bezhanova, Svetlana D.
Shubina, Irina Zh.
author_sort Kiselevskiy, Mikhail V.
collection PubMed
description Transmission of a malignancy from a donor’s organ to the recipient of the graft is a rare event, though it is a severe complication that can result in a poor outcome. Usually, immunosuppressive therapy is discontinued and the allograft is removed. However, treatment of patients with the disseminated cancers implies that after the graft removal and cessation of the immunosuppression, radiotherapy, chemotherapy, or immunotherapy with alpha-interferon (INF-α) or interleukin-2 (IL-2) are required. The case report presents a clinical case of a transmitted kidney graft with multiple metastases (MTS) in a 31-year-old woman with the spontaneous regression of the metastatic cancer after transplantectomy and cancellation of the immunosuppressive therapy. Obviously, the determining factor is the recognition of the tumor by the effectors of the antitumor immunity due to the human leukocyte antigen (HLA) mismatch between the donor and the recipient. Therefore, cancellation of the immunosuppressive therapy in cases of transferal of a malignancy with a transplanted organ allows the effectors of the immune system to distinguish the tumor as a foreign tissue and effectively eliminate this neoplasm.
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spelling pubmed-103448952023-07-15 Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft Kiselevskiy, Mikhail V. Gromova, Elena G. Kozlov, Nikolay A. Bezhanova, Svetlana D. Shubina, Irina Zh. Explor Target Antitumor Ther Case Report Transmission of a malignancy from a donor’s organ to the recipient of the graft is a rare event, though it is a severe complication that can result in a poor outcome. Usually, immunosuppressive therapy is discontinued and the allograft is removed. However, treatment of patients with the disseminated cancers implies that after the graft removal and cessation of the immunosuppression, radiotherapy, chemotherapy, or immunotherapy with alpha-interferon (INF-α) or interleukin-2 (IL-2) are required. The case report presents a clinical case of a transmitted kidney graft with multiple metastases (MTS) in a 31-year-old woman with the spontaneous regression of the metastatic cancer after transplantectomy and cancellation of the immunosuppressive therapy. Obviously, the determining factor is the recognition of the tumor by the effectors of the antitumor immunity due to the human leukocyte antigen (HLA) mismatch between the donor and the recipient. Therefore, cancellation of the immunosuppressive therapy in cases of transferal of a malignancy with a transplanted organ allows the effectors of the immune system to distinguish the tumor as a foreign tissue and effectively eliminate this neoplasm. Open Exploration Publishing 2023 2023-06-30 /pmc/articles/PMC10344895/ /pubmed/37455824 http://dx.doi.org/10.37349/etat.2023.00148 Text en © The Author(s) 2023. https://creativecommons.org/licenses/by/4.0/This is an Open Access article licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, sharing, adaptation, distribution and reproduction in any medium or format, for any purpose, even commercially, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Kiselevskiy, Mikhail V.
Gromova, Elena G.
Kozlov, Nikolay A.
Bezhanova, Svetlana D.
Shubina, Irina Zh.
Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft
title Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft
title_full Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft
title_fullStr Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft
title_full_unstemmed Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft
title_short Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft
title_sort spontaneous regression of a metastatic carcinoma transmitted by a kidney graft
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344895/
https://www.ncbi.nlm.nih.gov/pubmed/37455824
http://dx.doi.org/10.37349/etat.2023.00148
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