Chromatin structure and context-dependent sequence features control prime editing efficiency

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Prime editing (PE) is a highly versatile CRISPR–Cas9 genome editing technique. The current constructs, however, have variable efficiency and may require laborious experimental optimization. This study presents statistical models for learning the salient epigenomic and sequence features of target sit...

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Detalles Bibliográficos
Autores principales: Kim, Somang, Yuan, Jimmy B., Woods, Wendy S., Newton, Destry A., Perez-Pinera, Pablo, Song, Jun S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344898/
https://www.ncbi.nlm.nih.gov/pubmed/37456665
http://dx.doi.org/10.3389/fgene.2023.1222112

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