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Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation

Targeted protein degradation via “hijacking” of the ubiquitin-proteasome system using proteolysis targeting chimeras (PROTACs) has evolved into a novel therapeutic modality. The design of PROTACs is challenging; multiple steps involved in PROTAC-induced degradation make it difficult to establish coh...

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Detalles Bibliográficos
Autores principales:	Wurz, Ryan P., Rui, Huan, Dellamaggiore, Ken, Ghimire-Rijal, Sudipa, Choi, Kaylee, Smither, Kate, Amegadzie, Albert, Chen, Ning, Li, Xiaofen, Banerjee, Abhisek, Chen, Qing, Mohl, Dane, Vaish, Amit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344917/ https://www.ncbi.nlm.nih.gov/pubmed/37443112 http://dx.doi.org/10.1038/s41467-023-39904-5

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