O-GalNAc glycosylation determines intracellular trafficking of APP and Aβ production

A primary pathology of Alzheimer’s disease (AD) is amyloid β (Aβ) deposition in brain parenchyma and blood vessels, the latter being called cerebral amyloid angiopathy (CAA). Parenchymal amyloid plaques presumably originate from neuronal Aβ precursor protein (APP). Although vascular amyloid deposits...

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Detalles Bibliográficos
Autores principales: Tachida, Yuriko, Iijima, Junko, Takahashi, Kazuto, Suzuki, Hideaki, Kizuka, Yasuhiko, Yamaguchi, Yoshiki, Tanaka, Katsunori, Nakano, Miyako, Takakura, Daisuke, Kawasaki, Nana, Saito, Yuko, Manya, Hiroshi, Endo, Tamao, Kitazume, Shinobu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344954/
https://www.ncbi.nlm.nih.gov/pubmed/37302553
http://dx.doi.org/10.1016/j.jbc.2023.104905

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