RAGE inhibitor TTP488 (Azeliragon) suppresses metastasis in triple-negative breast cancer

Triple-negative breast cancer (TNBC) is a highly aggressive and metastatic cancer subtype, which is generally untreatable once it metastasizes. We hypothesized that interfering with the Receptor for Advanced Glycation End-products (RAGE) signaling with the small molecule RAGE inhibitors (TTP488/Azel...

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Detalles Bibliográficos
Autores principales: Magna, Melinda, Hwang, Gyong Ha, McIntosh, Alec, Drews-Elger, Katherine, Takabatake, Masaru, Ikeda, Adam, Mera, Barbara J., Kwak, Taekyoung, Miller, Philip, Lippman, Marc E., Hudson, Barry I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10344964/
https://www.ncbi.nlm.nih.gov/pubmed/37443146
http://dx.doi.org/10.1038/s41523-023-00564-9

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