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Leptospirosis kidney disease: Evolution from acute to chronic kidney disease

Leptospirosis is a neglected bacterial disease caused by leptospiral infection that carries a substantial mortality risk in severe cases. Research has shown that acute, chronic, and asymptomatic leptospiral infections are closely linked to acute and chronic kidney disease (CKD) and renal fibrosis. L...

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Autores principales: Chou, Li-Fang, Yang, Huang-Yu, Hung, Cheng-Chieh, Tian, Ya-Chung, Hsu, Shen-Hsing, Yang, Chih-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chang Gung University 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345244/
https://www.ncbi.nlm.nih.gov/pubmed/37142093
http://dx.doi.org/10.1016/j.bj.2023.100595
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author Chou, Li-Fang
Yang, Huang-Yu
Hung, Cheng-Chieh
Tian, Ya-Chung
Hsu, Shen-Hsing
Yang, Chih-Wei
author_facet Chou, Li-Fang
Yang, Huang-Yu
Hung, Cheng-Chieh
Tian, Ya-Chung
Hsu, Shen-Hsing
Yang, Chih-Wei
author_sort Chou, Li-Fang
collection PubMed
description Leptospirosis is a neglected bacterial disease caused by leptospiral infection that carries a substantial mortality risk in severe cases. Research has shown that acute, chronic, and asymptomatic leptospiral infections are closely linked to acute and chronic kidney disease (CKD) and renal fibrosis. Leptospires affect renal function by infiltrating kidney cells via the renal tubules and interstitium and surviving in the kidney by circumventing the immune system. The most well-known pathogenic molecular mechanism of renal tubular damage caused by leptospiral infection is the direct binding of the bacterial outer membrane protein LipL32 to toll-like receptor-2 expressed in renal tubular epithelial cells (TECs) to induce intracellular inflammatory signaling pathways. These pathways include the production of tumor necrosis factor (TNF)-α and nuclear factor kappa activation, resulting in acute and chronic leptospirosis-related kidney injury. Few studies have investigated the relationship between acute and chronic renal diseases and leptospirosis and further evidence is necessary. In this review, we intend to discuss the roles of acute kidney injury (AKI) to/on CKD in leptospirosis. This study reviews the molecular pathways underlying the pathogenesis of leptospirosis kidney disease, which will assist in concentrating on potential future research directions.
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spelling pubmed-103452442023-07-15 Leptospirosis kidney disease: Evolution from acute to chronic kidney disease Chou, Li-Fang Yang, Huang-Yu Hung, Cheng-Chieh Tian, Ya-Chung Hsu, Shen-Hsing Yang, Chih-Wei Biomed J Review Article Leptospirosis is a neglected bacterial disease caused by leptospiral infection that carries a substantial mortality risk in severe cases. Research has shown that acute, chronic, and asymptomatic leptospiral infections are closely linked to acute and chronic kidney disease (CKD) and renal fibrosis. Leptospires affect renal function by infiltrating kidney cells via the renal tubules and interstitium and surviving in the kidney by circumventing the immune system. The most well-known pathogenic molecular mechanism of renal tubular damage caused by leptospiral infection is the direct binding of the bacterial outer membrane protein LipL32 to toll-like receptor-2 expressed in renal tubular epithelial cells (TECs) to induce intracellular inflammatory signaling pathways. These pathways include the production of tumor necrosis factor (TNF)-α and nuclear factor kappa activation, resulting in acute and chronic leptospirosis-related kidney injury. Few studies have investigated the relationship between acute and chronic renal diseases and leptospirosis and further evidence is necessary. In this review, we intend to discuss the roles of acute kidney injury (AKI) to/on CKD in leptospirosis. This study reviews the molecular pathways underlying the pathogenesis of leptospirosis kidney disease, which will assist in concentrating on potential future research directions. Chang Gung University 2023-08 2023-05-02 /pmc/articles/PMC10345244/ /pubmed/37142093 http://dx.doi.org/10.1016/j.bj.2023.100595 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Chou, Li-Fang
Yang, Huang-Yu
Hung, Cheng-Chieh
Tian, Ya-Chung
Hsu, Shen-Hsing
Yang, Chih-Wei
Leptospirosis kidney disease: Evolution from acute to chronic kidney disease
title Leptospirosis kidney disease: Evolution from acute to chronic kidney disease
title_full Leptospirosis kidney disease: Evolution from acute to chronic kidney disease
title_fullStr Leptospirosis kidney disease: Evolution from acute to chronic kidney disease
title_full_unstemmed Leptospirosis kidney disease: Evolution from acute to chronic kidney disease
title_short Leptospirosis kidney disease: Evolution from acute to chronic kidney disease
title_sort leptospirosis kidney disease: evolution from acute to chronic kidney disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345244/
https://www.ncbi.nlm.nih.gov/pubmed/37142093
http://dx.doi.org/10.1016/j.bj.2023.100595
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