Successful Treatment of ALK-Positive Large-Cell Neuroendocrine Carcinoma of the Lung With Sequential ALK Inhibitors: A Case Report

ALK-positive large-cell neuroendocrine carcinoma (LCNEC) is an exceptionally rare form of lung cancer. The efficacy of ALK inhibitors in treating ALK-positive LCNEC remains unclear. Here, we report a case of ALK-positive LCNEC of the lung, which revealed a sustained clinical benefit (24+ mo of overa...

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Autores principales: Kobayashi, Takayuki, Uehara, Yuji, Watanabe, Kageaki, Hishima, Tsunekazu, Hosomi, Yukio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345342/
https://www.ncbi.nlm.nih.gov/pubmed/37456922
http://dx.doi.org/10.1016/j.jtocrr.2023.100538
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author Kobayashi, Takayuki
Uehara, Yuji
Watanabe, Kageaki
Hishima, Tsunekazu
Hosomi, Yukio
author_facet Kobayashi, Takayuki
Uehara, Yuji
Watanabe, Kageaki
Hishima, Tsunekazu
Hosomi, Yukio
author_sort Kobayashi, Takayuki
collection PubMed
description ALK-positive large-cell neuroendocrine carcinoma (LCNEC) is an exceptionally rare form of lung cancer. The efficacy of ALK inhibitors in treating ALK-positive LCNEC remains unclear. Here, we report a case of ALK-positive LCNEC of the lung, which revealed a sustained clinical benefit (24+ mo of overall survival) after treatment with sequential ALK inhibitors and local therapies. This remarkable improvement in survival underscores the importance of testing metastatic LCNEC for biomarkers, such as ALK rearrangement, using immunohistochemistry or next-generation sequencing, especially in younger patients.
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spelling pubmed-103453422023-07-15 Successful Treatment of ALK-Positive Large-Cell Neuroendocrine Carcinoma of the Lung With Sequential ALK Inhibitors: A Case Report Kobayashi, Takayuki Uehara, Yuji Watanabe, Kageaki Hishima, Tsunekazu Hosomi, Yukio JTO Clin Res Rep Case Report ALK-positive large-cell neuroendocrine carcinoma (LCNEC) is an exceptionally rare form of lung cancer. The efficacy of ALK inhibitors in treating ALK-positive LCNEC remains unclear. Here, we report a case of ALK-positive LCNEC of the lung, which revealed a sustained clinical benefit (24+ mo of overall survival) after treatment with sequential ALK inhibitors and local therapies. This remarkable improvement in survival underscores the importance of testing metastatic LCNEC for biomarkers, such as ALK rearrangement, using immunohistochemistry or next-generation sequencing, especially in younger patients. Elsevier 2023-06-15 /pmc/articles/PMC10345342/ /pubmed/37456922 http://dx.doi.org/10.1016/j.jtocrr.2023.100538 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kobayashi, Takayuki
Uehara, Yuji
Watanabe, Kageaki
Hishima, Tsunekazu
Hosomi, Yukio
Successful Treatment of ALK-Positive Large-Cell Neuroendocrine Carcinoma of the Lung With Sequential ALK Inhibitors: A Case Report
title Successful Treatment of ALK-Positive Large-Cell Neuroendocrine Carcinoma of the Lung With Sequential ALK Inhibitors: A Case Report
title_full Successful Treatment of ALK-Positive Large-Cell Neuroendocrine Carcinoma of the Lung With Sequential ALK Inhibitors: A Case Report
title_fullStr Successful Treatment of ALK-Positive Large-Cell Neuroendocrine Carcinoma of the Lung With Sequential ALK Inhibitors: A Case Report
title_full_unstemmed Successful Treatment of ALK-Positive Large-Cell Neuroendocrine Carcinoma of the Lung With Sequential ALK Inhibitors: A Case Report
title_short Successful Treatment of ALK-Positive Large-Cell Neuroendocrine Carcinoma of the Lung With Sequential ALK Inhibitors: A Case Report
title_sort successful treatment of alk-positive large-cell neuroendocrine carcinoma of the lung with sequential alk inhibitors: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345342/
https://www.ncbi.nlm.nih.gov/pubmed/37456922
http://dx.doi.org/10.1016/j.jtocrr.2023.100538
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