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First Report of Management of Sequential Small Cell Transformation and ALK I1171T Mutation as Resistance Mechanisms in a Patient With ALK-EML4 Fused Non–Small Cell Lung Adenocarcinoma With a Novel Combination of Temozolomide and Lorlatinib: A Case Report

ALK-EML4 fusion-positive lung adenocarcinomas (LUADs) are effectively treated with ALK tyrosine kinase inhibitors, but most patients eventually develop resistance to these drugs owing to ALK-dependent or independent mechanisms. Endothelial to mesenchymal transformation with SCLC development is an AL...

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Detalles Bibliográficos
Autores principales:	Majeed, Umair, Li, Shenduo, Seegobin, Karan, Nassar, Aziza, Manochakian, Rami, Zhao, Yujie, Lou, Yanyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Case Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345357/ https://www.ncbi.nlm.nih.gov/pubmed/37456921 http://dx.doi.org/10.1016/j.jtocrr.2023.100536

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