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Itaconic acid induces angiogenesis and suppresses apoptosis via Nrf2/autophagy to prolong the survival of multi-territory perforator flaps

BACKGROUND: Perforator flaps are widely used in hand microsurgery to reconstruct and repair soft tissue injuries. However, ischemia and subsequent ischemia-reperfusion injury may cause distal necrosis of the flap. Itaconic acid (IA) is a modulator of macrophage function, which exerts anti-inflammato...

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Detalles Bibliográficos
Autores principales:	Luo, Gaojie, Zhou, Zekun, Huang, Chengxiong, Zhang, Peiyao, Sun, Nianzhe, Chen, Wei, Deng, Chao, Li, Xiaoxiao, Wu, Panfeng, Tang, Juyu, Qing, Liming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345368/ https://www.ncbi.nlm.nih.gov/pubmed/37456049 http://dx.doi.org/10.1016/j.heliyon.2023.e17909

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