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Comparison of computed tomography and dual-energy X-ray absorptiometry in the evaluation of body composition in patients with obesity
OBJECTIVE: a) To evaluate the accuracy of the pre-existing equations (based on cm2 provided by CT images), to estimate in kilograms (Kg) the body composition (BC) in patients with obesity (PwO), by comparison with Dual-energy X-ray absorptiometry (DXA). b) To evaluate the accuracy of a new approach...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345841/ https://www.ncbi.nlm.nih.gov/pubmed/37455915 http://dx.doi.org/10.3389/fendo.2023.1161116 |
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author | Palmas, Fiorella Ciudin, Andreea Guerra, Raul Eiroa, Daniel Espinet, Carina Roson, Nuria Burgos, Rosa Simó, Rafael |
author_facet | Palmas, Fiorella Ciudin, Andreea Guerra, Raul Eiroa, Daniel Espinet, Carina Roson, Nuria Burgos, Rosa Simó, Rafael |
author_sort | Palmas, Fiorella |
collection | PubMed |
description | OBJECTIVE: a) To evaluate the accuracy of the pre-existing equations (based on cm2 provided by CT images), to estimate in kilograms (Kg) the body composition (BC) in patients with obesity (PwO), by comparison with Dual-energy X-ray absorptiometry (DXA). b) To evaluate the accuracy of a new approach (based on both cm2 and Hounsfield Unit parameters provided by CT images), using an automatic software and artificial intelligence to estimate the BC in PwO, by comparison with DXA. METHODS: Single-centre cross-sectional study including consecutive PwO, matched by gender with subjects with normal BMI. All the subjects underwent BC assessment by Dual-energy X-ray absorptiometry (DXA) and skeletal-CT at L3 vertebrae. CT images were processed using FocusedON-BC software. Three different models were tested. Model 1 and 2, based on the already existing equations, estimate the BC in Kg based on the tissue area (cm2) in the CT images. Model 3, developed in this study, includes as additional variables, the tissue percentage and its average Hounsfield unit. RESULTS: 70 subjects (46 PwO and 24 with normal BMI) were recruited. Significant correlations for BC were obtained between the three models and DXA. Model 3 showed the strongest correlation with DXA (r= 0.926, CI95% [0.835-0.968], p<0.001) as well as the best agreement based on Bland – Altman plots. CONCLUSION: This is the first study showing that the BC assessment based on skeletal CT images analyzed by automatic software coupled with artificial intelligence, is accurate in PwO, by comparison with DXA. Furthermore, we propose a new equation that estimates both the tissue quantity and quality, that showed higher accuracy compared with those currently used, both in PwO and subjects with normal BMI. |
format | Online Article Text |
id | pubmed-10345841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103458412023-07-15 Comparison of computed tomography and dual-energy X-ray absorptiometry in the evaluation of body composition in patients with obesity Palmas, Fiorella Ciudin, Andreea Guerra, Raul Eiroa, Daniel Espinet, Carina Roson, Nuria Burgos, Rosa Simó, Rafael Front Endocrinol (Lausanne) Endocrinology OBJECTIVE: a) To evaluate the accuracy of the pre-existing equations (based on cm2 provided by CT images), to estimate in kilograms (Kg) the body composition (BC) in patients with obesity (PwO), by comparison with Dual-energy X-ray absorptiometry (DXA). b) To evaluate the accuracy of a new approach (based on both cm2 and Hounsfield Unit parameters provided by CT images), using an automatic software and artificial intelligence to estimate the BC in PwO, by comparison with DXA. METHODS: Single-centre cross-sectional study including consecutive PwO, matched by gender with subjects with normal BMI. All the subjects underwent BC assessment by Dual-energy X-ray absorptiometry (DXA) and skeletal-CT at L3 vertebrae. CT images were processed using FocusedON-BC software. Three different models were tested. Model 1 and 2, based on the already existing equations, estimate the BC in Kg based on the tissue area (cm2) in the CT images. Model 3, developed in this study, includes as additional variables, the tissue percentage and its average Hounsfield unit. RESULTS: 70 subjects (46 PwO and 24 with normal BMI) were recruited. Significant correlations for BC were obtained between the three models and DXA. Model 3 showed the strongest correlation with DXA (r= 0.926, CI95% [0.835-0.968], p<0.001) as well as the best agreement based on Bland – Altman plots. CONCLUSION: This is the first study showing that the BC assessment based on skeletal CT images analyzed by automatic software coupled with artificial intelligence, is accurate in PwO, by comparison with DXA. Furthermore, we propose a new equation that estimates both the tissue quantity and quality, that showed higher accuracy compared with those currently used, both in PwO and subjects with normal BMI. Frontiers Media S.A. 2023-06-26 /pmc/articles/PMC10345841/ /pubmed/37455915 http://dx.doi.org/10.3389/fendo.2023.1161116 Text en Copyright © 2023 Palmas, Ciudin, Guerra, Eiroa, Espinet, Roson, Burgos and Simó https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology Palmas, Fiorella Ciudin, Andreea Guerra, Raul Eiroa, Daniel Espinet, Carina Roson, Nuria Burgos, Rosa Simó, Rafael Comparison of computed tomography and dual-energy X-ray absorptiometry in the evaluation of body composition in patients with obesity |
title | Comparison of computed tomography and dual-energy X-ray absorptiometry in the evaluation of body composition in patients with obesity |
title_full | Comparison of computed tomography and dual-energy X-ray absorptiometry in the evaluation of body composition in patients with obesity |
title_fullStr | Comparison of computed tomography and dual-energy X-ray absorptiometry in the evaluation of body composition in patients with obesity |
title_full_unstemmed | Comparison of computed tomography and dual-energy X-ray absorptiometry in the evaluation of body composition in patients with obesity |
title_short | Comparison of computed tomography and dual-energy X-ray absorptiometry in the evaluation of body composition in patients with obesity |
title_sort | comparison of computed tomography and dual-energy x-ray absorptiometry in the evaluation of body composition in patients with obesity |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345841/ https://www.ncbi.nlm.nih.gov/pubmed/37455915 http://dx.doi.org/10.3389/fendo.2023.1161116 |
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