Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins

When considering the vesicle-associated membrane protein-associated protein (VAP) family, major receptors at the surface of the endoplasmic reticulum (ER), it appears that VAP-A and VAP-B paralogs largely overlap in structure and function, and that specific features to distinguish these two proteins...

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Detalles Bibliográficos
Autores principales: Subra, Mélody, Grimanelli, Zoé, Gautier, Romain, Mesmin, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345920/
https://www.ncbi.nlm.nih.gov/pubmed/37455812
http://dx.doi.org/10.1177/25152564231183897
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author Subra, Mélody
Grimanelli, Zoé
Gautier, Romain
Mesmin, Bruno
author_facet Subra, Mélody
Grimanelli, Zoé
Gautier, Romain
Mesmin, Bruno
author_sort Subra, Mélody
collection PubMed
description When considering the vesicle-associated membrane protein-associated protein (VAP) family, major receptors at the surface of the endoplasmic reticulum (ER), it appears that VAP-A and VAP-B paralogs largely overlap in structure and function, and that specific features to distinguish these two proteins hardly exist or are poorly documented. Here, we question the degree of redundancy between VAP-A and VAP-B: is one simply a backup plan, in case of loss of function of one of the two genes, or are there molecular and functional divergences that would explain their maintenance during evolution?
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spelling pubmed-103459202023-07-15 Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins Subra, Mélody Grimanelli, Zoé Gautier, Romain Mesmin, Bruno Contact (Thousand Oaks) Opinion When considering the vesicle-associated membrane protein-associated protein (VAP) family, major receptors at the surface of the endoplasmic reticulum (ER), it appears that VAP-A and VAP-B paralogs largely overlap in structure and function, and that specific features to distinguish these two proteins hardly exist or are poorly documented. Here, we question the degree of redundancy between VAP-A and VAP-B: is one simply a backup plan, in case of loss of function of one of the two genes, or are there molecular and functional divergences that would explain their maintenance during evolution? SAGE Publications 2023-07-12 /pmc/articles/PMC10345920/ /pubmed/37455812 http://dx.doi.org/10.1177/25152564231183897 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Opinion
Subra, Mélody
Grimanelli, Zoé
Gautier, Romain
Mesmin, Bruno
Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins
title Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins
title_full Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins
title_fullStr Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins
title_full_unstemmed Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins
title_short Stranger Twins: A Tale of Resemblance and Contrast Between VAP Proteins
title_sort stranger twins: a tale of resemblance and contrast between vap proteins
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345920/
https://www.ncbi.nlm.nih.gov/pubmed/37455812
http://dx.doi.org/10.1177/25152564231183897
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