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Stress hyperglycemia ratio and long‐term prognosis in patients with acute coronary syndrome: A multicenter, nationwide study

BACKGROUND: Stress hyperglycemia ratio (SHR), a novel biomarker of stress hyperglycemia, was proved to be a reliable predictor of short‐term adverse outcomes in patients with acute coronary syndromes (ACS). However, its impact on long‐term prognosis remained controversial. METHODS: A total of 7662 p...

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Autores principales: Zeng, Guyu, Song, Ying, Zhang, Zheng, Xu, Jingjing, Liu, Zhenyu, Tang, Xiaofang, Wang, XiaoZeng, Chen, Yan, Zhang, Yongzhen, Zhu, Pei, Guo, Xiaogang, Jiang, Lin, Wang, Zhifang, Liu, Ru, Wang, Qingsheng, Yao, Yi, Feng, Yingqing, Han, Yaling, Yuan, Jinqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Publishing Asia Pty Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345977/
https://www.ncbi.nlm.nih.gov/pubmed/37132473
http://dx.doi.org/10.1111/1753-0407.13400
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author Zeng, Guyu
Song, Ying
Zhang, Zheng
Xu, Jingjing
Liu, Zhenyu
Tang, Xiaofang
Wang, XiaoZeng
Chen, Yan
Zhang, Yongzhen
Zhu, Pei
Guo, Xiaogang
Jiang, Lin
Wang, Zhifang
Liu, Ru
Wang, Qingsheng
Yao, Yi
Feng, Yingqing
Han, Yaling
Yuan, Jinqing
author_facet Zeng, Guyu
Song, Ying
Zhang, Zheng
Xu, Jingjing
Liu, Zhenyu
Tang, Xiaofang
Wang, XiaoZeng
Chen, Yan
Zhang, Yongzhen
Zhu, Pei
Guo, Xiaogang
Jiang, Lin
Wang, Zhifang
Liu, Ru
Wang, Qingsheng
Yao, Yi
Feng, Yingqing
Han, Yaling
Yuan, Jinqing
author_sort Zeng, Guyu
collection PubMed
description BACKGROUND: Stress hyperglycemia ratio (SHR), a novel biomarker of stress hyperglycemia, was proved to be a reliable predictor of short‐term adverse outcomes in patients with acute coronary syndromes (ACS). However, its impact on long‐term prognosis remained controversial. METHODS: A total of 7662 patients with ACS from a large nationwide prospective cohort between January 2015 and May 2019 were included. SHR was calculated by the following formula: SHR = admission glucose (mmol/L)/(1.59 × HbA1c [%]−2.59). The primary end point was a major adverse cardiovascular event (MACE) during follow‐up, a composite of all‐cause death, myocardial infarction, and unplanned revascularization. The second end point was the separate components of the primary end points. RESULTS: During a median follow‐up of 2.1 years, 779 MACE events occurred. After multivariable adjustment, ACS patients with the highest SHR tertile were significantly associated with increased long‐term risks of MACE (hazard ratio [HR] 1.53, 95% confidence interval [CI] 1.24–1.88), all‐cause death (HR 1.80, 95% CI 1.29–2.51) and unplanned revascularization (HR 1.44, 95% CI 1.09–1.91). Although significant associations between the highest SHR tertile and risks of MACE and all‐cause death were assessed in both diabetic and nondiabetic patients, the patterns of risk were different in these two groups. CONCLUSION: Elevated SHR was independently associated with a higher risk of long‐term outcomes irrespective of diabetic status, suggesting that SHR was a potential biomarker for risk stratification after ACS.
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spelling pubmed-103459772023-07-15 Stress hyperglycemia ratio and long‐term prognosis in patients with acute coronary syndrome: A multicenter, nationwide study Zeng, Guyu Song, Ying Zhang, Zheng Xu, Jingjing Liu, Zhenyu Tang, Xiaofang Wang, XiaoZeng Chen, Yan Zhang, Yongzhen Zhu, Pei Guo, Xiaogang Jiang, Lin Wang, Zhifang Liu, Ru Wang, Qingsheng Yao, Yi Feng, Yingqing Han, Yaling Yuan, Jinqing J Diabetes Editor's Recommendations BACKGROUND: Stress hyperglycemia ratio (SHR), a novel biomarker of stress hyperglycemia, was proved to be a reliable predictor of short‐term adverse outcomes in patients with acute coronary syndromes (ACS). However, its impact on long‐term prognosis remained controversial. METHODS: A total of 7662 patients with ACS from a large nationwide prospective cohort between January 2015 and May 2019 were included. SHR was calculated by the following formula: SHR = admission glucose (mmol/L)/(1.59 × HbA1c [%]−2.59). The primary end point was a major adverse cardiovascular event (MACE) during follow‐up, a composite of all‐cause death, myocardial infarction, and unplanned revascularization. The second end point was the separate components of the primary end points. RESULTS: During a median follow‐up of 2.1 years, 779 MACE events occurred. After multivariable adjustment, ACS patients with the highest SHR tertile were significantly associated with increased long‐term risks of MACE (hazard ratio [HR] 1.53, 95% confidence interval [CI] 1.24–1.88), all‐cause death (HR 1.80, 95% CI 1.29–2.51) and unplanned revascularization (HR 1.44, 95% CI 1.09–1.91). Although significant associations between the highest SHR tertile and risks of MACE and all‐cause death were assessed in both diabetic and nondiabetic patients, the patterns of risk were different in these two groups. CONCLUSION: Elevated SHR was independently associated with a higher risk of long‐term outcomes irrespective of diabetic status, suggesting that SHR was a potential biomarker for risk stratification after ACS. Wiley Publishing Asia Pty Ltd 2023-05-03 /pmc/articles/PMC10345977/ /pubmed/37132473 http://dx.doi.org/10.1111/1753-0407.13400 Text en © 2023 The Authors. Journal of Diabetes published by Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Editor's Recommendations
Zeng, Guyu
Song, Ying
Zhang, Zheng
Xu, Jingjing
Liu, Zhenyu
Tang, Xiaofang
Wang, XiaoZeng
Chen, Yan
Zhang, Yongzhen
Zhu, Pei
Guo, Xiaogang
Jiang, Lin
Wang, Zhifang
Liu, Ru
Wang, Qingsheng
Yao, Yi
Feng, Yingqing
Han, Yaling
Yuan, Jinqing
Stress hyperglycemia ratio and long‐term prognosis in patients with acute coronary syndrome: A multicenter, nationwide study
title Stress hyperglycemia ratio and long‐term prognosis in patients with acute coronary syndrome: A multicenter, nationwide study
title_full Stress hyperglycemia ratio and long‐term prognosis in patients with acute coronary syndrome: A multicenter, nationwide study
title_fullStr Stress hyperglycemia ratio and long‐term prognosis in patients with acute coronary syndrome: A multicenter, nationwide study
title_full_unstemmed Stress hyperglycemia ratio and long‐term prognosis in patients with acute coronary syndrome: A multicenter, nationwide study
title_short Stress hyperglycemia ratio and long‐term prognosis in patients with acute coronary syndrome: A multicenter, nationwide study
title_sort stress hyperglycemia ratio and long‐term prognosis in patients with acute coronary syndrome: a multicenter, nationwide study
topic Editor's Recommendations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10345977/
https://www.ncbi.nlm.nih.gov/pubmed/37132473
http://dx.doi.org/10.1111/1753-0407.13400
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